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Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21R110

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Fig. 1: Clinicobiological profile of IGLV3-21R110 CLL.


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The authors would like to thank all patients, their families, and investigators involved in the HOVON-139/GIVE and HOVON-141/VIsion trials. In addition, the authors would like to acknowledge Mr. Jorn Assmann and Miss. Lina van der Straten for their participation in constructive discussions that have significantly improved the manuscript.


The HOVON-139/GIVE trial was funded by F Hoffmann-La Roche (ML29995), who had the opportunity to review and comment on this paper. The HOVON-141/VIsion trial was supported by AbbVie and Janssen/Pharmacyclics, who had the opportunity to review and comment on this paper. In addition, the HOVON-141/VIsion trial was funded by the Novo Nordisk Foundation grant NNF160C0019302.

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Authors and Affiliations



PJH, MDL, and AWL conceived of the study. PJH and YEE performed the light chain sequencing. JMND, SK, CUN, APK, and MDL were involved in designing, operating and biobanking the HOVON-139/GIVE and/or HOVON-141/VIsion trials and facilitated the availability of the samples. CHMM, AMvdKK, ORFM, and MMM performed and analyzed the genomic array and targeted NGS analysis. LME performed the heavy-chain sequencing. KH assisted in primer design. PMK contributed to the data analysis. PJH, MDL, AWL, PMK, and PEW interpreted and reviewed the data. PJH, MDL, and AWL wrote the manuscript. All authors critically read and approved the final version of the manuscript.

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Correspondence to Mark-David Levin.

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Competing interests

SK has received personal fees from Janssen, AbbVie, Novartis, Gilead, and Celgene; and research funding from AbbVie, Janssen, AstraZeneca, and Roche/Genentech. CUN received research funding and/or consultancy fees from Abbvie, AstraZeneca, Roche, Janssen, CSL Behring, Takeda, and Octapharma. APK has received personal fees from AbbVie, LAVA, Genmab, Janssen, AstraZeneca, Roche/Genentech, and Bristol Myers Squibb; and research funding from AbbVie, Janssen, AstraZeneca, Roche/Genentech, and Bristol Myers Squibb. AWL has received research support via an unrestricted grant from Roche-Genentech and a speaker-fee from Janssen. M-DL has received personal fees from AbbVie, Janssen, and Roche; and research funding from AbbVie, Janssen, AstraZeneca, and Roche/Genentech. All other authors declare no competing interests.

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Hengeveld, P.J., Ertem, Y.E., Dubois, J.M.N. et al. Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21R110. Leukemia 36, 1935–1938 (2022).

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