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STEM CELL TRANSPLANTATION

Baricitinib prevents GvHD by increasing Tregs via JAK3 and treats established GvHD by promoting intestinal tissue repair via EGFR

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Fig. 1: BARI increases GvHD-suppressive Tregs by preserving JAK3 signaling.
Fig. 2: Inhibition of EGFR signaling by erlotinib diminishes GvHD recovery mediated by BARI.

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Acknowledgements

JC is supported by Amy Strelzer Manasevit Research Program (the Be The Match Foundation and the National Marrow Donor Program), Alvin J. Siteman Cancer Center Siteman Investment Program (supported by the Foundation for Barnes-Jewish Hospital Cancer Frontier Fund, National Cancer Institute Cancer Center Support Grant, P30 CA091842, and Barnard Trust), Bigelow Aerospace (OTM 13489), Washington University SPORE-CDP in Leukemia (P50 CA171963), Washington University DDRCC grant (P30 DK052574), and the Bryan Thomas Campbell Foundation. JFD is supported by Bigelow Aerospace (OTM 13489), Washington University NCI/NIH SPORE in Leukemia (P50 CA171963), NCI Outstanding Investigator Award (R35 CA210084), and the Bryan Thomas Campbell Foundation. KA is supported by Washington University SPORE Diversity Program (P50 CA171963). MAC is supported by R01DK109384 and The Lawrence C. Pakula MD IBD Research Fund at Washington University.

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Conceptualization: JFD and JC; methodology: SK, KA, JFD and JC; investigation and validation: SK, KA, SL, KS, KV, SS, JR, SP, FG, MAC, JC; formal analysis: SK, KA, SL, KS, KV, SS, JC; writing for the first version of the manuscript: SK, KA, JC; visualization: SK, KA, SL, KS, JC; supervision: JC; funding acquisition: JFD and JC.

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Correspondence to Jaebok Choi.

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Competing interests

JC received honorarium from Incyte Corporation, received research funding from Mallinckrodt Pharmaceuticals, and served as a consultant for Daewoong Pharmaceutical. JFD served on advisory boards for Incyte Corporation, CellWorks, Macrogenics, Amphivena, Arch, Rivervest, and Bioline and is a co-Founder of Magenta Therapeutics and WUGen. MLC is a co-Founder and Chief Scientific Officer of WUgen. MAC previously had research grants from Incyte Corporation. The other authors declare no conflict of interest.

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Kim, S., Ashami, K., Lim, S. et al. Baricitinib prevents GvHD by increasing Tregs via JAK3 and treats established GvHD by promoting intestinal tissue repair via EGFR. Leukemia (2021). https://doi.org/10.1038/s41375-021-01360-9

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