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Multiple myeloma, gammopathies

Long-term follow-up of subcutaneous versus intravenous bortezomib during induction therapy for newly diagnosed multiple myeloma treated within the GMMG-MM5 Phase III Trial

Leukemia volume 35, pages 3007–3011 (2021)Cite this article

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Fig. 1: Flow chart and survival analyses of the GMMG MM5 trial.

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Acknowledgements

The GMMG-MM5 trial was supported by Celgene, Janssen-Cilag, Chugai, and The Binding Site. The GMMG thanks the Koordinierungszentrum für Klinische Studien (KKS) Heidelberg for the support of the trial and data monitoring. The GMMG thanks all participating investigators and centers.

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Authors and Affiliations

  1. Asklepios Tumorzentrum Hamburg, AK Altona, Hamburg, Germany

    Hans Salwender

  2. Department of Hematology/Oncology and Stem Cell Transplantation, AK St. Georg, Hamburg, Germany

    Ahmet Elmaagacli & Christian Jehn

  3. Department of Hematology, Celltherapy and Hemostaseology, University Hospital of Leipzig, Leipzig, Germany

    Maximilian Merz

  4. Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany

    Kaya Miah & Axel Benner

  5. Klinikum Chemnitz, Chemnitz, Germany

    Mathias Haenel

  6. Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

    Elias K. Mai, Uta Bertsch, Marc S. Raab & Hartmut Goldschmidt

  7. National Center for Tumor Diseases (NCT), Heidelberg, Germany

    Uta Bertsch & Hartmut Goldschmidt

  8. Charité Universitätsmedizin, Berlin, Germany

    Igor W. Blau

  9. University Hospital Cologne, Cologne, Germany

    Christof Scheid

  10. Vrije Universiteit Brussel (VUB), Laboratory of Hematology and Immunology & Labor für Myelomforschung, Jette, Belgium

    Dirk Hose & Anja Seckinger

  11. Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany

    Anna Jauch

  12. Coordination Centre for Clinical Trials (KKS), Heidelberg, Germany

    Steffen P. Luntz

  13. University Hospital Tubingen, Tubingen, Germany

    Britta Besemer

  14. University Medical Center Mainz, Mainz, Germany

    Markus Munder

  15. University Hospital Bonn, Bonn, Germany

    Peter Brossart

  16. Helios Hospital Berlin Buch, Buch, Germany

    Stephan Fuhrmann

  17. Kath. Krankenhaus Hagen, Hagen, Germany

    Hans-Walter Lindemann

  18. University Hospital Hamburg, Hamburg, Germany

    Katja Weisel

  19. University Hospital Essen, Essen, Germany

    Jan Duerig

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  1. Hans Salwender
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Contributions

Conception and design: HS, MMe, HG, UB, KM, and AB. Responsible statisticians: KM and AB. Administrative support: HG, UB, and SPL. Provision of study materials or patients and/or collection, assembly and review of data: all authors. Data analysis and interpretation: HS, AE, MMe, HG, EKM, KM, and AB. Writing of the first manuscript draft: HS, AE, MMe, and HG. Manuscript editing, discussion of trial data/results, and final writing: all authors. Final approval of manuscript: all authors.

Corresponding author

Correspondence to Hans Salwender.

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Conflict of interest

HS: honoraria: AbbVie, Amgen, BMS, Celgene, Chugai, GSK, Janssen, Oncopeptides, Sanofi, Sebia, Takeda; travel, accommodations, expenses: Amgen, BMS, Celgene, Janssen, Sanofi. AE: honoraria: Janssen, Celgene, Takeda; consulting or advisory role: Janssen, Amgen, Celgene, Takeda, Sanofi; travel, accommodations, expenses: Janssen, Takeda, Celgene, Amgen, Novartis. MMe: consulting or advisory role: BMS, Amgen, Takeda; research funding: Takeda; travel, accommodations, expenses: Celgen, AMGEN, Takeda, Abbvie, Janssen. KM: no COI AB: no COI MHä: honoraria: Novartis, Amgen, Roche, Takeda; consulting or advisory role: Celgene. CJ: honoraria: Janssen, Celgene, Takeda; consulting or advisory role: Janssen, Amgen, Celgene, Takeda, Sanofi; travel, accommodations, expenses: Janssen, Takeda, Celgene, Amgen, Novartis EKM: honoraria: Janssen, Celgene, Takeda, GSK; consulting or advisory role: Janssen, Celgene, Takeda, GSK; research funding: Takeda; travel, accomodations, expenses: Janssen, Takeda, Celgene, Onyx, BMS, Mundipharma. UB: no COI IWB: research funding: Celgene, BMS, Janssen. CS: honoraria: BMS, Janssen, Celgene, Novartis, Amgen, Takeda; consulting or advisory role: BMS, Janssen, Celgene, Novartis, Amgen, Takeda; speakers bureau: Takeda; research funding: Takeda, Novartis; travel, accommodations, expenses: BMS, Janssen, Celgene, Novartis, Amgen, Takeda. DH: consulting or advisory role: I. Lamkap Bio AG. Discoveric AG; research funding: Celgene AG. Sanofi. Engmab AG; travel, accommodations, expenses: Celgene. AS: consulting or advisory role: I. Lamkap Bio AG. Discoveric AG; research funding: Celgene AG. Sanofi. Engmab AG. AJ: no COI MSR: consulting or advisory role, travel support: BMS, Amgen, Incyte, Takeda, Novartis, Janssen, AbbVie, Sanofi, Roche; Research Funding: Amgen, Novartis, Sanofi SPL: no COI BB: honoraria: Janssen-Cilag, GSK, Takeda. MMu: honoraria: Janssen, BMS, Takeda, Celgene, Amgen, GSK, Sanofi-Genzyme; consulting or advisory role: Janssen, BMS, Takeda, Celgene, Amgen, GSK; research funding: BMS, Incyte; travel, accomodations, expenses: Janssen, BMS, Takeda, Amgen. PB: consulting or advisory role: BMS, AMGEN, Roche, MSD; research funding: BMS; travel, accommodations, expenses: BMS. SF: consulting or advisory role: Amgen, BMS, Celgene, Sanofi, Janssen. H-WL: no COI KW: Grants from Amgen, Celgene, Sanofi, Janssen (all to the institution), honoraria and advisory board from Amgen, BMS, Celgene, Adaptive Biotech, Janssen, GSK, Karyopharm, Roche, Sanofi, Takeda, Oncopeptides. JD: consulting or advisory role: Celgene; speakers bureau: Celgene; travel, accommodations, expenses: Celgene. HG: Grants and/or provision of Investigational Medicinal Product: Amgen, BMS, Celgene, Chugai, Dietmar-Hopp-Foundation, Janssen, Johns Hopkins University, Sanofi. Research Support: Amgen, BMS, Celgene, Chugai, Janssen, Incyte, Molecular Partners, Merck Sharp and Dohme (MSD), Sanofi, Mundipharma GmbH, Takeda, Novartis. Advisory Boards: Adaptive Biotechnology, Amgen, BMS, Celgene, Janssen, Sanofi, Takeda. Honoraria: Amgen, BMS, Celgene, Chugai, GlaxoSmithKline (GSK), Janssen, Novartis, Sanofi.

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Salwender, H., Elmaagacli, A., Merz, M. et al. Long-term follow-up of subcutaneous versus intravenous bortezomib during induction therapy for newly diagnosed multiple myeloma treated within the GMMG-MM5 Phase III Trial. Leukemia 35, 3007–3011 (2021). https://doi.org/10.1038/s41375-021-01298-y

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