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Tefferi A, Barbui T. Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification and management. Am J Hematol 2012;92:94–108.
Stahl RL, Silber R. Vasculitis leg ulcers in chronic myelogenous leukemia. Am J Med. 1985;78:869–872.
Montefusco E, Alimena G, Gastaldi R, Carlesimo OA, Valesini G, Mandelli F. Unusual dermatologic toxicity of long-term therapy with hydroxyurea in chronic myelogenous leukemia. Tumori 1986;72:317–321.
Barosi G, Besses C, Birgegard G, Briere J, Cervantes F, Finazzi G, et al. A unified definition of clinical resistance /intolerance to hydroxycarbamide in essential thrombocythemia: results of a consensus process by an international working group. Leukemia 2007;21:277–280.
Barosi G, Birgegard G, Finazzi G, Griesshammer M, Harrison C, Hasselbalch H, et al. A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythemia vera and primary myelofibrosis: results of a European LeukemiaNet (ELN) consensus process. Br J Haematol. 2010;148:961–963.
Antar A, Ishak RS, Otrock ZK, El-Majzoub N, Ghosn S, Mahfouz R, et al. Successful treatment of hydroxyurea-associated chronic leg ulcers associated with squamous cell carcinoma. Hematol Oncol Stem Cell Ther. 2014;7:166–169.
Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, et al. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N. Engl J Med. 2005;353:33–45.
Randi ML, Ruzzon E, Tezza F, Luzzatto G, Fabris F. Toxicity and side effects of hydroxyurea used for primary thrombocythemia. Platelets 2005;16:181–184.
Antonioli E, Guglielmelli P, Pieri L, Finazzi M, Rumi E, Martinelli V, et al. Hydroxyurea-related toxicity in 3,411 patients with Ph-negative MPN. Am J Hematol. 2012;87:552–554.
Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009;114:937–951.
Barbui T, Barosi G, Birgegard G, Cervantes F, Finazzi G, Griesshammer M, et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol. 2011;29:761–70.
Beses C, Garcia-Pallarol F, Angona A, Marta B, Daniel LC, Concepción F-R, et al. Hydroxyurea mucocutaneous toxicity: a prospective cohort study of 110 ET and PV patients from a single institution. Blood 2017;130:4208. abstract
Christiane Fuchs was supported by the German Research Foundation within the SFB 1243, Subproject A17.
Conflict of interest
The authors KW, HB, CF, SS, PS, TB, VK, HD, RS declare that there are no competing interests in relation to the work described; FS reports speaker bureau and consultancy for BMS, Incyte, Novartis, and Pfizer, KD for BMS, Celgene, CTI, Novartis, and Roche, MG for AOP Orphan, Celgene, CTI, Novartis, and Shire.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
A full list of board members of the German Study Group-MPN (GSG-MPN) and their affiliations appears in the Supplementary Information.
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Stegelmann, F., Wille, K., Busen, H. et al. Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN) - on behalf of the German Study Group-MPN. Leukemia 35, 628–631 (2021). https://doi.org/10.1038/s41375-020-0945-3