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Decreased cell stiffness enhances leukemia development and progression


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Fig. 1: Deletion of Ptpn21 promotes development and progression of MLL-AF9-induced leukemia.
Fig. 2: Cellular mechanical properties but not cell signaling activities are impacted in Ptpn21-deleted MLL leukemic cells that proliferate faster than control cells in vivo.


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This work was supported by the National Institutes of Health grants HL130995 and DK092722, and a St. Baldrick’s Foundation reseach grant (to C-KQ).

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LH, FN, and XW conducted mouse experiments and summarized the data. MEF performed microfluidics assays. KMY performed the Atomic Force Microscope measurements. WAL and TAS provided critical advice. C-KQ designed the experiments and directed the entire project. LH, FN, and C-KQ wrote the manuscript.

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Correspondence to Cheng-Kui Qu.

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Hu, L., Ni, F., Wang, X. et al. Decreased cell stiffness enhances leukemia development and progression. Leukemia 34, 2493–2497 (2020).

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