Acute lymphoblastic leukemia

Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms

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The authors would like to thank Ms. Natsuko Ariizumi, Ms. Shinobu Kobayashi, and Ms. Yoshie Fukumasa for their technical assistance. We also thank Mr. Yukinori Yatsuda (Bio-rad) for his assistance with the ddPCR analysis. The authors thank Mr. James R. Valera of the Department of Education for Clinical Research of the National Center for Child Health and Development for his assistance in proofreading and editing this manuscript. This study was supported in part by the Japan Society for the Promotion of Science (JSPS) through a Grant-in-Aid for Scientific Research (KAKENHI, grant number 17H04234), by a grant from the National Center for Child Health and Development (grant numbers 28-5), by grant 17km0405107h0005, 17ck0106253h0001, and 17ck0106219h0002 from the Japan Agency for Medical Research and development, (AMED), and by foundation for National Institutes of Health (GM118578, GM115279, and P30CA21765) and the V Foundation for Cancer Research (T2015-006). T.M is supported by the Garwood Fellowship at St. Jude Children’s Research Hospital.

Author contributions

MK is the principal investigator and takes primary responsibility for the paper, designed this study, interpreted data, wrote the manuscript, and gave final approval; ST, TO collected data, analyzed data, interpreted data, and wrote the manuscript; TO evaluated patients, collected data, analyzed data, interpreted data, and wrote the manuscript; MU, RS, TM, RN, YY, TU, NK and JJY collected data, analyzed data, interpreted data. KK, MS, YA, KT, SI, KK, JT, EI and DT evaluated patients, and collected data; All authors discussed the results and critically reviewed the manuscript.

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Correspondence to Motohiro Kato.

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The authors declare that they have no conflict of interest.

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Tsujimoto, S., Osumi, T., Uchiyama, M. et al. Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms. Leukemia 32, 2710–2714 (2018).

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