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This study was funded by grants from the Academy of Finland (#274474, #312492, and #284538), the Sigrid Juselius Foundation, Helsinki University Hospital Comprehensive Cancer Research Funding, and The Finnish Funding Agency for Technology and Innovation (TEKES). We are extremely grateful to patients who participated and thus made this study possible. We thank FuGU and the FIMM Technology Center for excellent exome/Sanger sequencing services; Minna Suvela, Siv Knaappila, Annukka Ruokolainen, and Pihla Siipola for excellent technical assistance. The Aaltonen laboratory, especially Riku Katainen, is thanked for help in bioinformatics and the exome control files.
OK and UW-K designed the study. UW-K collected the clinical data, analyzed the results, and drafted the manuscript. EAMH analyzed the exome data, validated the mutations, and drafted the manuscript together with OK and UW-K. EP brought new ideas to the data analysis and contributed to the statistical analyses. JS, KK, and CH organized the exome sequencing at FIMM. KP organized the exome sequencing and major funding for the project. All authors have read and approved the manuscript.
Conflict of interest
The authors declare that they have no conflict of interest.
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Wartiovaara-Kautto, U., Hirvonen, E.A.M., Pitkänen, E. et al. Germline alterations in a consecutive series of acute myeloid leukemia. Leukemia 32, 2282–2285 (2018). https://doi.org/10.1038/s41375-018-0049-5
Nature Communications (2021)