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Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma

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Acknowledgements

We are indebted to the patients for donating tumor specimens as part of this study. The authors thank the Centre de Ressources Biologiques (CRB)-Santé of Rennes (BB-0033-00056) for patient samples, Queen Mary University of London Genome Centre for Illumina Miseq sequencing, and the support by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London for Illumina Hiseq sequencing. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. This work was supported by grants from the Kay Kendall Leukaemia Fund (KKL 757 awarded to J.O.), Cancer Research UK (22742 awarded to J.O., 15968 awarded to J.F., Clinical Research Fellowship awarded to S.A.), Bloodwise through funding of the Precision Medicine for Aggressive Lymphoma (PMAL) consortium, Centre for Genomic Health, Queen Mary University of London, Carte d’Identité des Tumeurs (CIT), Ligue National contre le Cancer, Pôle de biologie hospital universitaire de Rennes, CRB-Santé of Rennes (BB-0033-00056), and CeVi/Carnot program.

Author contributions

J.O. conceived the study; S.A., J.F., J.W., and J.O. designed the study; S.A., J.W., K.K., J.F., and J.O. wrote the manuscript; C.P., J.K.D., P.J., S.M., R.A., J.G.G., and T.G. identified patients for the study and collected clinical information; E.K., S.I., and A.C. prepared DNA samples; M.C. performed pathological review of specimens; J.W., C.C., and T.G. performed the bioinformatic analysis; S.A., K.K., C.P., E.K., T.R., A.R.-M., and J.H. performed experiments; S.A., J.W., K.K., E.K., T.R., J.H., A.R.-M, and J.O. analyzed the data. All authors read, critically reviewed, and approved the manuscript.

Author information

Author notes

    Affiliations

    1. Centre for Haemato-Oncology, Barts Cancer Institute, London, UK

      • Shamzah Araf
      • , Koorosh Korfi
      • , Eleni Kotsiou
      • , Ana Rio-Machin
      • , Tahrima Rahim
      • , James Heward
      • , Andrew Clear
      • , Sameena Iqbal
      • , Jeff K. Davies
      • , Maria Calaminici
      • , Silvia Montoto
      • , Rebecca Auer
      • , John G. Gribben
      • , Jude Fitzgibbon
      •  & Jessica Okosun
    2. Centre for Genomic Health, Queen Mary University of London, London, UK

      • Shamzah Araf
    3. Centre for Molecular Oncology, Barts Cancer Institute, London, UK

      • Jun Wang
      •  & Claude Chelala
    4. UMR INSERM 1236, Université de Rennes, 1, EFS de Bretagne, CHU de Rennes, Rennes, France

      • Celine Pangault
      •  & Thierry Fest
    5. Cancer Sciences Unit, Cancer Research UK Centre, Southampton, UK

      • Peter Johnson
    6. Evolution and Cancer Laboratory, Barts Cancer Institute, London, UK

      • Trevor Graham

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    Conflict of interest

    The authors declare that they have no conflict of interest

    Corresponding authors

    Correspondence to Shamzah Araf or Jessica Okosun.

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