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Evaluation of lung volumes and gas exchange in surfactant-deficient rabbits between variable and fixed servo pressures during high-frequency jet ventilation

Journal of Perinatology volume 44, pages 266–272 (2024)Cite this article

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Abstract

Objective

To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress.

Study design

Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal study using rabbits (n = 10, mean weight = 1.80 kg) with surfactant deficiency by repeated lung lavages.

Results

Rabbits in the fixed SP group had greater peak inspiratory pressure, SP, minute volume, pH, and PaO2, and lower PaCO2 after lung lavage than the variable SP group. Lung volume monitoring with electrical impedance tomography showed that fixed SP reduced the decline of the global lung tidal variation at 30 min after lung lavage (−17.4% from baseline before lavage) compared to variable SP (−44.9%).

Conclusion

HFJV with fixed SP significantly improved gas exchange and lung volumes compared to variable SP. Applying a fixed SP may have important clinical implications for patients receiving HFJV.

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Fig. 1: Time schedule for animal procedures.
Fig. 2: Ventilation parameters.
Fig. 3: Blood gas exchange and indices of disease severity.
Fig. 4: Estimates of lung volume loss and recovery with electrical impedance tomography (EIT).

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Data availability

The raw data can be made available upon request by contacting the corresponding author.

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Author information

Authors and Affiliations

  1. Center for Respiratory Biology and Therapeutics, Seattle Children’s Research Institute, Seattle, WA, USA

    Robert M. DiBlasi, Patrik Malone & Masaki Kajimoto

  2. Department of Respiratory Care, Seattle Children’s Hospital, Seattle, WA, USA

    Robert M. DiBlasi, Tina Romo & Patrik Malone

  3. Critical Care Transport, Seattle Children’s Hospital, Seattle, WA, USA

    Kellie J. Micheletti

  4. Bunnell Inc, Salt Lake City, UT, USA

    Jeff Orth & Evan Richards

  5. Department of Pediatrics, Alpert Medical School of Brown University, Providence, RI, USA

    Justin R. Goldstein & Martin Keszler

Authors
  1. Robert M. DiBlasi
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  2. Kellie J. Micheletti
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  3. Tina Romo
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  4. Patrik Malone
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  5. Jeff Orth
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  6. Evan Richards
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  7. Masaki Kajimoto
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  8. Justin R. Goldstein
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  9. Martin Keszler
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Contributions

RMD, MK, and JRG conceptualized the study, and JO and ER provided technical feedback where required. RMD, KJM, TR, PM, MK, and ER conducted animal experiments in the DiBlasi Laboratory at Seattle Children’s Research Institute, Seattle, WA. RMD, MK, JRG, and MK collected, analyzed, and interpreted all data. All authors reviewed the manuscript and provided feedback.

Corresponding author

Correspondence to Robert M. DiBlasi.

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Competing interests

RMD received funding from Bunnell, Inc. to conduct this preclinical research. He has also disclosed relationships with Medtronic, Draeger Medical, and ABM Respiratory Medical. JO is the Chief Technology Officer, and ER is Bunnell’s Advanced Practice Clinical Consultant. MK has disclosed relationships with Bunnell Inc. and Draeger Medical. All other authors have nothing to disclose.

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DiBlasi, R.M., Micheletti, K.J., Romo, T. et al. Evaluation of lung volumes and gas exchange in surfactant-deficient rabbits between variable and fixed servo pressures during high-frequency jet ventilation. J Perinatol 44, 266–272 (2024). https://doi.org/10.1038/s41372-023-01832-z

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  • DOI: https://doi.org/10.1038/s41372-023-01832-z

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