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Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?

Journal of Perinatology volume 44, pages 301–306 (2024)Cite this article

Subjects

Abstract

Objective

Examine the relationship between weight trajectory and 2-year neurodevelopmental outcomes for extremely low birthweight (ELBW) infants with BPD.

Study design

Secondary analysis of infants born from 2010 to 2019. The predictor was BPD severity and the outcome was neurodevelopmental impairment, defined as any Bayley Scales of Infant Development (BSID) III score <70 at 24 months’ corrected age. Repeated measures logistic regression was performed.

Results

In total, 5042 infants were included. Faster weight trajectory was significantly associated with a decreased probability of having at least one BSID III score <70 for infants with grade 1–2 BPD (p < 0.0001) and an increased probability of at least one BSID III score <70 for infants with grade 3 BPD (p < 0.009). There was no significant association between weight trajectory and BSID III score <70 for infants with grade 0 BPD.

Conclusion

The association between postnatal weight trajectory and neurodevelopmental outcome in this study differs by BPD severity.

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Fig. 1: Predicted probability of having any BSID III score less than 70 according to change in weight z-score.

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Data availability

Access to the Vermont Oxford Network Extremely Low Birth Weight Follow-Up database can be granted by emailing EME (eedwards@vtoxford.org).

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Funding

Funding

EME receives a grant from Vermont Oxford Network.

Author information

Authors and Affiliations

  1. Division of Neonatology, Oregon Health & Science University, Portland, OR, USA

    Fernando A. Munoz & Emily Hawkins Carter

  2. Vermont Oxford Network, Burlington, VT, USA

    Erika M. Edwards

  3. College of Engineering and Mathematical Sciences, University of Vermont, Burlington, VT, USA

    Erika M. Edwards

  4. Robert Larner, MD, College of Medicine, University of Vermont, Burlington, VT, USA

    Erika M. Edwards

  5. Graduate Programs in Human Nutrition, Oregon Health & Science University, Portland, OR, USA

    Maggie Jerome

  6. Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Jonathan S. Litt

  7. Department of Pediatrics, Harvard Medical School, Boston, MA, USA

    Jonathan S. Litt

  8. Department of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, Boston, MA, USA

    Jonathan S. Litt

Authors
  1. Fernando A. Munoz
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  2. Emily Hawkins Carter
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  3. Erika M. Edwards
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  4. Maggie Jerome
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  5. Jonathan S. Litt
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Contributions

FAM contributed to study conceptualization and design, data interpretation, and drafted the initial manuscript. EHC and JSL contributed to study conceptualization and design, data interpretation, and revision of the manuscript. EME was responsible for data acquisition, initial analysis, creation of tables and figures, and contributed to revision of the manuscript. MJ contributed to data interpretation and revision of the manuscript. All authors approve the final manuscript as submitted.

Corresponding author

Correspondence to Fernando A. Munoz.

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Competing interests

The authors declare no competing interests.

Ethical approval

No IRB or other ethics board approval was required for this study. This study was completed in accordance with the Declaration of Helsinki.

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Munoz, F.A., Carter, E.H., Edwards, E.M. et al. Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?. J Perinatol 44, 301–306 (2024). https://doi.org/10.1038/s41372-023-01808-z

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  • DOI: https://doi.org/10.1038/s41372-023-01808-z

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