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Can the triglyceride-glucose index predict insulin resistance in LGA newborns?

Journal of Perinatology volume 43, pages 1119–1124 (2023)Cite this article

Subjects

Abstract

Background

The aim of this study is to investigate the TyG index and TG/HDL-C ratio and their relationships with insulin resistance in LGA infants.

Methods

A prospective controlled study was conducted including 65 LGA and gestational age, gender-matched appropriate for gestational age (AGA) neonates. Serum TG, total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), insulin and glucose levels were measured within two hours after birth, TyG index and HOMA-IR values were calculated.

Results

TyG index and TG/HDL- C ratio were higher in LGA neonates compared to AGA ones (p = 0.03; p = 0.00, respectively). Compared with AGA newborns, LGA newborns had higher levels of insulin and HOMA-IR (p = 0.00; p = 0.00, respectively). TyG index and TG/HDL-C ratio showed moderate correlation with HOMA-IR (r = 0.59 R2 = 0.35 p < 0.001; r = 0.5 R2 = 0.25 p < 0.001, respectively).

Conclusıon

The results of this study show that LGA newborns have increased levels of TyG index and TG/HDL-C associated with insulin resistance.

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Fig. 1: The correlations between TyG index, TG/HDL-C and HOMA-IR.

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Data availability

The data is available for this study.

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Author information

Authors and Affiliations

  1. Department of Neonatology, Etlik Zubeyde Hanım Women’s Health Training and Research Hospital, University of Health Sciences, Ankara, Turkey

    Sumru Kavurt, Safiye Elif Uzlu & Mehtap Tosun

  2. Department of Neonatology, Ankara Yıldırım Beyazıt University, Ankara, Turkey

    Ahmet Yagmur Bas & Nihal Demirel

  3. Department of Perinatology, Etlik Zubeyde Hanım Women’s Health Training and Research Hospital, University of Health Sciences, Ankara, Turkey

    Şevki Çelen

  4. Department of Obstetrics and Gynecology, Etlik Zubeyde Hanım Women’s Health Training and Research Hospital, University of Health Sciences, Ankara, Turkey

    Yaprak Engin Üstün

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  1. Sumru Kavurt
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Contributions

1st author: Design and writing of the article with literature review. 2nd, and 4th author: Data analysis. 3rd,5th, and 6th author: Literature review and revision of manuscript. 7th author: Revision of the manuscript.

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Correspondence to Sumru Kavurt.

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Ethical approval

The protocol was approved by the Local Ethics Committee of Etlik Zubeyde Hanım Women’s Health Training and Research Hospital, Ankara City Hospital. Informed written consent was obtained from the parents before enrollment.

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Kavurt, S., Uzlu, S.E., Bas, A.Y. et al. Can the triglyceride-glucose index predict insulin resistance in LGA newborns?. J Perinatol 43, 1119–1124 (2023). https://doi.org/10.1038/s41372-022-01586-0

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