Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Impact of early-onset sepsis guidelines on breastfeeding

Abstract

Objective

To evaluate the impact of changes to neonatal early-onset sepsis (EOS) guidelines on in-hospital breastfeeding.

Study design

Asymptomatic neonates admitted to the Neonatal Intensive Care Unit (NICU) for sepsis evaluations over a 2-year period were identified. A retrospective chart review was conducted as part of a larger quality initiative on antibiotic stewardship.

Result

In Epoch 1, Epoch 2, and Epoch 3, there were 268 babies, 138 babies and 138 babies admitted to the NICU based on sepsis protocol, respectively. When comparing Epoch 1 to Epoch 3, there was a 14% increase in total breast milk consumption rates (p < 0.0001) and a 15% increase in exclusive breastfeeding at discharge (p < 0.002).

Conclusion

By implementing new EOS protocols, we have decreased NICU length of stay. We suggest that the decrease in mother–infant separation time leads to an improvement in breastfeeding.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Exclusive breastfeeding at discharge through PDSA cycles.
Fig. 2: Comparing exclusive breastfeeding at discharge.

Similar content being viewed by others

References

  1. Duijts L, Jaddoe VW, Hofman A, Moll HA. Prolonged and exclusive breastfeeding reduces the risk of infectious disease in infancy. Pediatrics. 2010;126:e18–25.

    Article  Google Scholar 

  2. Lodge CJ, Tan DJ, Lau MX, Dai X, Tham R, Lowe AJ, et al. Breastfeeding and asthma and allergies: a systematic review and meta-analysis. Acta Paediatr. 2015;104:38–53.

    Article  CAS  Google Scholar 

  3. Hauck FR, Thompson JM, Tanabe KO, Moon R, Vennemann MM. Breastfeeding and reduced risk of sudden infant death syndrome: a meta-analysis. Pediatrics. 2011;128:103–10.

    Article  Google Scholar 

  4. Horta BL, deSousa BA, de Mola CL. Breastfeeding and neurodevelopmental outcomes. Curr Opin Clin Nutr Metab Care. 2018;21:174–8.

    Article  Google Scholar 

  5. Chowdhury R, Sinha B, Sankar MJ, Taneja S, Bhandari N, Rollins N, et al. Breastfeeding and maternal health outcomes: a systematic review and meta-analysis. Acta Paediatr. 2015;104:96–113.

    Article  Google Scholar 

  6. World Health Organization. Global nutrition targets 2025: breastfeeding policy brief. Geneva: World Health Organization; 2014.

  7. AAP Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 2012;129:e827–841.

    Article  Google Scholar 

  8. Moore ER, Bergman N, Anderson GC, Medley N. Early skin-to-skin contact for mothers and their healthy newborn infants. Cochrane Database Syst Rev. 2016;11:CD003519.

    PubMed  Google Scholar 

  9. Dewey KG, Nommsen-Rivers LA, Heinig MJ, Cohen RJ. Risk factors for suboptimal infant breastfeeding behavior, delayed onset of lactation, and excess neonatal weight loss. Pediatrics. 2003;112:607–19.

    Article  Google Scholar 

  10. Polin RA, Papile L, Baley J, Benitz W, Carlo W, Cummings J, et al. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics. 2012;129:1006–15.

    Article  Google Scholar 

  11. Benitz WE, Wynn JL, Polin RA. Reappraisal of guidelines for management of neonates with suspected early-onset sepsis. J Pediatr. 2015;166:1070–4.

    Article  Google Scholar 

  12. Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, et al. Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors. Pediatrics. 2011;128:e1155–63.

    Article  Google Scholar 

  13. Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, et al. Stratification of risk of early-onset sepsis in newborns > 34 weeks’ gestation. Pediatrics. 2014;133:30–6.

    Article  Google Scholar 

  14. Kuzniewicz MW, Walsh EM, Li S, Fischer A, Escobar GJ. Development and implementation of an early-onset sepsis calculator to guide antibiotic management in late preterm and term neonates. Jt Comm J Qual Patient Saf. 2016;42:232–9.

    PubMed  Google Scholar 

  15. Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, et al. A quantitative, risk-based approach to the management of neonatal early-onset sepsis. JAMA Pediatr. 2017;171:365–71.

    Article  Google Scholar 

  16. Carola D, Vasconcellos M, Sloane A, McElwee D, Edwards C, Greenspan J, et al. Utility of early-onset sepsis risk calculator for neonates born to mothers with choriamnionitis. J Pediatr. 2018;195:48–52.

    Article  Google Scholar 

  17. Ellington M, Kasat K, Williams K, Reichman V, Degoy A, Gonzalez Ballesteros L, et. al. Improving antibiotic stewardship among asymptomatic newborns using the early onset sepsis risk calculator. Pediatr Qual Saf. 2021 (in press).

  18. Mukhopadhyay S, Lieberman ES, Puopolo KM, Riley LE, Johnson L. Effect of early-onset sepsis evaluations on in-hospital breastfeeding practices among asymptomatic term neonates. Hosp Pediatr. 2015;5:203–10.

    Article  Google Scholar 

  19. Shim M, Yang S, Messina CR, Mintzer JP. Discharge breastmilk feeding rates in asymptomatic term newborns admitted to the neonatal intensive care unit for maternal chorioamnionitis. J Matern Fetal Neonatal Med. 2019;32:2688–93.

    Article  Google Scholar 

  20. Hooven TA, Randis TM, Polin RA. What’s the harm? Risks and benefits of evolving rule-out sepsis practices. J Perinatol. 2018;38:614–22.

    Article  Google Scholar 

  21. World Health Organization. Comprehensive implementation plan on maternal, infant and young child nutrition. World Health Organization: Geneva, 2014.

  22. Holmes A. Establishing successful breastfeeding in the newborn period. Pediatr Clin N Am. 2013;60:147–68.

    Article  Google Scholar 

  23. Balogun OO, O’Sullivan EJ, McFadden A, Ota E, Gavin A, Garner CD, et al. Interventions for promoting the initiation of breastfeeding. Cochrane Database Syst Rev. 2016;11:CD001688.

    PubMed  Google Scholar 

  24. Walker TC, Keene SD, Patel RM. Early feeding factors associated with exclusive versus partial human milk feeding in neonates receiving intensive care. J Perinatol. 2014;34:606–10.

    Article  CAS  Google Scholar 

  25. Jones KM, Power ML, Queenan JT, Schulkin J. Racial and ethnic disparities in breastfeeding. Breastfeed Med. 2015;10:186–96.

    Article  Google Scholar 

  26. Hobbs AJ, Mannion CA, McDonald SW, Brockway M, Tough SC. The impact of caesarean section on breastfeeding initiation, duration and difficulties in the first four months postpartum. BMC Pregnancy Childbirth. 2016;16:90.

    Article  Google Scholar 

  27. Lau Y, Tha PH, Ho-Lim SST, Wong LY, Lim PI, Nurfarah B, et al. An analysis of the effects of intrapartum factors, neonatal characteristics, and skin-to-skin contact on early breastfeeding initiation. Matern Child Nutr. 2018;14:e12492.

    Article  Google Scholar 

  28. McFadden A, Gavine A, Renfrew MJ, Wad A, Buchanan P, Taylor JL, et al. Support for health breastfeeding mother with healthy term babies. Cochrane Database Syst Rev. 2017;2:CD001141.

    PubMed  Google Scholar 

  29. Peterson D, Hoffman SB, El-Metwally D, Martino-Gomez M, Chinta DR, Hughes, et al. Management of asymptomatic neonates born in the setting of chorioamnionitis: a safety comparison of the well-baby and intensive care setting. J Perinatol. 2017;37:1236–41.

    Article  CAS  Google Scholar 

  30. Joshi NS, Gupta A, Allan JM, Cohen RS, Aby JL, Weldon B, et al. Clinical monitoring of well-appearing infants born to mothers with chorioamnionitis. Pediatrics. 2018;141:1–8.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

KK was responsible for study design, data collection, and writing the manuscript. SA was responsible for statistical analysis. SS and SZ collected data and assisted with analyzing results. ME assisted with writing manuscript and data interpretation.

Corresponding author

Correspondence to Kavita Kasat.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kasat, K., Ahn, S., Smith, S. et al. Impact of early-onset sepsis guidelines on breastfeeding. J Perinatol 41, 2499–2504 (2021). https://doi.org/10.1038/s41372-021-01154-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-021-01154-y

Search

Quick links