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Readmissions in neonatal ECMO survivors: a pediatric health information system database analysis

Journal of Perinatology volume 41, pages 1777–1781 (2021)Cite this article

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Extracorporeal membrane oxygenation (ECMO) is a lifesaving treatment for critically ill neonates. While there is some information on hospital readmissions and survival in non-neonatal pediatric and adult ECMO patients, there is little published data reporting readmission for neonatal ECMO survivors [1, 2]. Currently, providers are unable to prognosticate readmission and opportunities for quality improvement for this high-risk infant group [3]. With this in mind, we analyzed the Pediatric Health Information System (PHIS) database over a 10-year period. The goals of this analysis were to (1) establish early and late readmission rates, (2) identify associated demographic, socioeconomic, and co-morbidity factors, (3) and to determine prognosticators regarding readmission in ECMO survivors.

Data were obtained from the PHIS database from January 2005 to September 2015. PHIS is an administrative pediatric database that includes clinical and resource utilization data for inpatient, ambulatory surgery, emergency department, and observation unit patient encounters for over 45 not-for-profit pediatric hospitals affiliated with Children’s Hospital Association. The study was approved by the Human Subjects Protection Program at Children’s Hospital Los Angeles (CHLA-14-00480).

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Fig. 1: The adjusted association of readmissions and covariates within 365 and 30 days.

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Acknowledgements

We would like to acknowledge the support of the Teresa and Byron Pollitt Family Chair in Fetal & Neonatal Medicine. This is a prognostic study, with Level II evidence.

Funding

Dr. Lakshmanan is supported by grants from the Sharon D. Lund Foundation and the Zumberge Diversity and Inclusion Award and Dr. Kelley-Quon by a NIH career development award, KL2TR001854.

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Authors and Affiliations

  1. Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Ashley Song, Cynthia L. Gong, Leah Yieh, Philippe Friedlich, Rachel Chapman & Ashwini Lakshmanan

  2. Deparment of Preventive Medicine, Johns Hopkins University, Baltimore, MD, USA

    Ashley Song

  3. Division of Pediatric Surgery, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    Michael Fenlon, Lorraine I. Kelley-Quon, Philippe Friedlich & Rachel Chapman

  4. Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Michael Fenlon & Lorraine I. Kelley-Quon

  5. Department of Preventive Medicine, University of Southern California, Los Angeles, USA

    Lorraine I. Kelley-Quon & Ashwini Lakshmanan

  6. Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA, USA

    Cynthia L. Gong, Leah Yieh & Ashwini Lakshmanan

Authors
  1. Ashley Song
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  2. Michael Fenlon
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  3. Lorraine I. Kelley-Quon
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  4. Cynthia L. Gong
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  5. Leah Yieh
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  6. Philippe Friedlich
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  7. Rachel Chapman
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  8. Ashwini Lakshmanan
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Contributions

Dr. Song made contributions to analyzing the data and interpreting the results. Dr. Song wrote the first draft of the manuscript. Drs. Fenlon, Kelley-Quon, Gong, Yieh, Chapman, and Friedlich made contributions to interpreting the results and reviewing the manuscript. Dr. Lakshmanan made substantial contributions to designing the study, analyzing the data, and interpreting the results. All authors reviewed and approved of the final version of the manuscript.

Corresponding author

Correspondence to Ashwini Lakshmanan.

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Song, A., Fenlon, M., Kelley-Quon, L.I. et al. Readmissions in neonatal ECMO survivors: a pediatric health information system database analysis. J Perinatol 41, 1777–1781 (2021). https://doi.org/10.1038/s41372-021-01077-8

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  • DOI: https://doi.org/10.1038/s41372-021-01077-8

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