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Revisiting the definition of bronchopulmonary dysplasia in premature infants at a single center quaternary neonatal intensive care unit

Journal of Perinatology volume 41, pages 756–763 (2021)Cite this article

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A Correction to this article was published on 07 September 2021

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Abstract

Objective

To compare the incidence of bronchopulmonary dysplasia (BPD) based on the 1988 Vermont Oxford Network (VON) criteria, National Institutes of Health (NIH) 2001 definition, and NIH 2018 definition.

Methods

BPD incidence by each definition was compared in premature infants born at a single center between 2016 and 2018. Comorbidities were compared between those with and without BPD according to the newest definition.

Results

Among 352 survivors, BPD incidence was significantly different at 9%, 28% and 34% according to VON, NIH 2001 and NIH 2018 definitions, respectively (p < 0.05). According to the newest definition, any grade of BPD was associated with more co-morbidities than those without BPD (P < 0.001).

Conclusion

At a center that emphasizes use of early noninvasive respiratory support, the incidence of BPD was significantly higher according to the NIH 2018 definition compared to other two definitions. The relationship between BPD diagnosis and long-term clinical outcomes remains unclear.

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Fig. 1: Bronchopulmonary dysplasia incidence and subgroup severity based on the VON definition, NIH 2001 and NIH 2018 definitions.

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Acknowledgements

We would like to thank Kiyoko Ohira-Kist for her time and effort in collecting and inputting our institution’s data into the Vermont Oxford Network Database.

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Authors and Affiliations

  1. NewYork- Presbyterian Children’s Hospital of New York, Columbia University Medical Center, New York, NY, USA

    Faith Kim, David A. Bateman, Nimrod Goldshtrom, Rakesh Sahni, Jen Tien Wung & Aaron Wallman-Stokes

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  1. Faith Kim
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  2. David A. Bateman
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  3. Nimrod Goldshtrom
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  4. Rakesh Sahni
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  5. Jen Tien Wung
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Contributions

FK and AW-S conceptualized and designed the study, designed the data collection instruments, collected data and drafted the initial manuscript and reviewed and revised the manuscript. DAB and NG carried out secondary analyses and reviewed and revised the manuscript. RS and JTW reviewed and revised the manuscript. All authors approved the final manuscript and agree to be accountable for all aspects of the work.

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Correspondence to Faith Kim.

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The authors declare no competing interests.

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The original online version of this article was revised: Table 3 was corrected.

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Kim, F., Bateman, D.A., Goldshtrom, N. et al. Revisiting the definition of bronchopulmonary dysplasia in premature infants at a single center quaternary neonatal intensive care unit. J Perinatol 41, 756–763 (2021). https://doi.org/10.1038/s41372-021-00980-4

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