Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Journal Club
  • Published:

Does high-dose erythropoietin decrease the risk of death or severe neurodevelopmental impairment in preterm infants?

Journal of Perinatology volume 41, pages 1505–1510 (2021)Cite this article

Subjects

Manuscript citation: Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, et al. A randomized trial of erythropoietin for neuroprotection in preterm infants. N Engl J Med. 2020;382(3):233–43. https://doi.org/10.1056/NEJMoa1907423

In extremely preterm infants born at 24 weeks 0 days to 27 weeks 6 days, does high-dose erythropoietin (EPO) administered from 24 h after birth through 32 weeks postmenstrual age, decrease the risk of death or severe neurodevelopmental impairment at 22–26 months postmenstrual age, compared to placebo?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, et al. A randomized trial of erythropoietin for neuroprotection in preterm infants. N Engl J Med. 2020;382:233–43. https://doi.org/10.1056/NEJMoa1907423

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ. Outcomes for extremely premature infants. Anesth Analg. 2015;120:1337–51. https://doi.org/10.1213/ANE.0000000000000705

    Article  PubMed  PubMed Central  Google Scholar 

  3. Broglio K. Randomization in clinical trials: permuted blocks and stratification. JAMA 2018;319:2223–4. https://doi.org/10.1001/jama.2018.6360

    Article  PubMed  Google Scholar 

  4. Nair J, Kumar V. Is glucose variability associated with worse brain function and seizures in neonatal encephalopathy? J Perinatol. 2020;40:827–30. https://doi.org/10.1038/s41372-020-0651-z

    Article  PubMed  Google Scholar 

  5. Anchan JC, Carr NR, Ahmad KA. Neonatal hypoglycemia: is there a neurodevelopmental impact in early childhood? J Perinatol. 2019;39:4–7. https://doi.org/10.1038/s41372-018-0244-2

    Article  PubMed  Google Scholar 

  6. Marlow N, Wolke D, Bracewell MA, Samara M, EPICure Study Group. Neurologic and developmental disability at six years of age after extremely preterm birth. N. Engl J Med. 2005;352:9–19. https://doi.org/10.1056/NEJMoa041367

    Article  CAS  PubMed  Google Scholar 

  7. Wong HS, Santhakumaran S, Cowan FM, Modi N, Medicines for Neonates Investigator Group. Developmental assessments in preterm children: a meta-analysis. Pediatrics. 2016;138:e20160251 https://doi.org/10.1542/peds.2016-0251

    Article  PubMed  Google Scholar 

  8. Fischer HS, Reibel NJ, Bührer C, Dame C. Prophylactic early erythropoietin for neuroprotection in preterm infants: a meta-analysis. Pediatrics. 2017;139:e20164317 https://doi.org/10.1542/peds.2016-4317

    Article  PubMed  Google Scholar 

  9. White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice. Stat Med 2011;30:377–99. https://doi.org/10.1002/sim.4067

    Article  PubMed  Google Scholar 

  10. Pigott TD. A review of methods for missing data. Educ Res Evaluation. 2001;7:353–83.

    Article  Google Scholar 

  11. Azur MJ, Stuart EA, Frangakis C, Leaf PJ. Multiple imputation by chained equations: what is it and how does it work? Int J Methods Psychiatr Res. 2011;20:40–49. https://doi.org/10.1002/mpr.329

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The Journal club is a collaboration between the American Academy of Pediatrics- Section of Neonatal Perinatal medicine and the International Society of Evidence- based neonatology (EBNEO.org)

Author information

Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Molly Crimmins Easterlin & Rangasamy Ramanathan

Authors
  1. Molly Crimmins Easterlin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rangasamy Ramanathan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Molly Crimmins Easterlin.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Easterlin, M.C., Ramanathan, R. Does high-dose erythropoietin decrease the risk of death or severe neurodevelopmental impairment in preterm infants?. J Perinatol 41, 1505–1510 (2021). https://doi.org/10.1038/s41372-021-00931-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-021-00931-z

Search

Advanced search

Quick links