Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Journal Club
  • Published:

Does a lower interventional glucose threshold affect neurodevelopment in at-risk neonates?

Journal of Perinatology volume 41, pages 1180–1183 (2021)Cite this article

Subjects

Manuscript citation: van Kempen AAMW, Eskes PF, Nuytemans DHGM, van der Lee JH, Dijksman LM, van Veenendaal NR, et al. Lower versus traditional treatment threshold for neonatal hypoglycemia. N Engl J Med. 2020;382(6):534–44.

In neonates born at >35 weeks gestation who require hypoglycemia screening, does a lower glucose treatment threshold (36 mg/dL) compared to a traditional glucose threshold (47 mg/dL) affect psychomotor development at 18 months?

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Harris DL, Alsweiler JM, Ansell JM, Gamble GD, Thompson B, Wouldes TA, et al. Outcome at 2 years after dextrose gel treatment for neonatal hypoglycemia: follow-up of a randomized trial. J Pediatr. 2016;170:54–9.

    Article  CAS  Google Scholar 

  2. Kaiser JR, Bai S, Gibson N, Holland G, Lin TM, Swearingen CJ, et al. Association between transient newborn hypoglycemia and fourth-grade achievement test proficiency: a population-based study. JAMA Pediatr. 2015;169:913–21.

    Article  Google Scholar 

  3. Shah R, Harding J, Brown J, McKinlay C. Neonatal glycaemia and neurodevelopmental outcomes: a systematic review and meta-analysis. Neonatology. 2019;115:116–26.

    Article  CAS  Google Scholar 

  4. McKinlay CJD, Alsweiler JM, Ansell JM, Anstice NS, Chase JG, Gamble GD, et al. Neonatal glycemia and neurodevelopmental outcomes at 2 years. NEJM. 2015;373:1507–18.

    Article  CAS  Google Scholar 

  5. AAP Committee on Fetus and Newborn. Postnatal glucose homeostasis in late-preterm and term infants. Pediatrics. 2011;127:575–9.

    Article  Google Scholar 

  6. Thornton PS, Stanley CA, De Leon DD, Harris D, Haymond MW, Hussain K, et al. Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children. J Pediatr. 2015;167:238–45.

    Article  Google Scholar 

  7. Mukhopadhyay S, Wade KC, Dhudasia MB, Skerritt L, Chou JH, Dukhovny D, et al. Clinical impact of neonatal hypoglycemia screening in the well-baby care. J Perinatol. 2020;40:1331–8.

    Article  Google Scholar 

  8. Sanchez MM, Chen X. Choosing the analysis population in non-inferiority studies: per protocol or intent-to-treat. Stat Med. 2006;25:1169–81.

    Article  Google Scholar 

  9. Schumi J, Wittes J. Through the looking glass: understanding non-inferiority. Trials. 2011;12:106.

    Article  Google Scholar 

Download references

Acknowledgements

The Journal club is a collaboration between the American Academy of Pediatrics—Section of Neonatal Perinatal Medicine and the International Society of Evidence-based Neonatology (EBNEO.org).

Author information

Author notes

  1. These authors contributed equally: Carolyn McGann, Sarah A. Coggins

Authors and Affiliations

  1. Division of Neonatology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Carolyn McGann & Sarah A. Coggins

  2. Division of Neonatology, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Kevin Dysart

Authors
  1. Carolyn McGann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sarah A. Coggins
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kevin Dysart
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carolyn McGann.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

McGann, C., Coggins, S.A. & Dysart, K. Does a lower interventional glucose threshold affect neurodevelopment in at-risk neonates?. J Perinatol 41, 1180–1183 (2021). https://doi.org/10.1038/s41372-021-00921-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-021-00921-1

Search

Advanced search

Quick links