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Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants

Journal of Perinatology volume 40, pages 1296–1300 (2020)Cite this article

Subjects

Abstract

Objective

Evaluate association between fluid balance and intraventricular hemorrhage (IVH).

Study design

Retrospective review of infants <30 weeks gestation admitted to Kentucky Children’s Hospital Neonatal Intensive Care Unit.

Results

Infants with acute kidney injury (AKI) had a 2.4-fold increased risk of IVH (OR 2.38, 95% CI 1.46–3.87) and a 3.5-fold increased risk of severe IVH (OR 3.45, 95% CI 1.98–6.04). Infants above birthweight on day 4 had a 1.9-fold increased risk of IVH (OR 1.86, 95% CI 1.05–3.27) and a 2.0-fold increased risk of severe IVH (OR 1.96, 95% CI 1.03–3.74). When controlling for confounding factors, infants with AKI or above birthweight on day 4 had a 4.6-fold (aOR 4.60, 95% CI 1.80–11.78) and 3.0-fold (aOR 2.96, 95% CI 1.01–8.65) increased risk of severe IVH, respectively.

Conclusion

Infants with AKI during the first week of life had a higher association of severe IVH even after controlling for confounding factors.

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Fig. 1: Incidence of AKI and IVH.
Fig. 2: Fluid balance and IVH.

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Acknowledgements

We acknowledge Kelly Wilson, DO for her helpful data collection effort.

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Authors and Affiliations

  1. East Tennessee State University, Johnson City, TN, USA

    Brittnea Adcock

  2. University of Kentucky, Lexington, KY, USA

    Sean Carpenter, John Bauer, Peter Giannone, Aric Schadler, Aftab Chishti & Mina Hanna

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  1. Brittnea Adcock
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  2. Sean Carpenter
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Correspondence to Brittnea Adcock.

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Adcock, B., Carpenter, S., Bauer, J. et al. Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants. J Perinatol 40, 1296–1300 (2020). https://doi.org/10.1038/s41372-020-0613-5

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