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The association between preeclampsia and ICD diagnosis of neonatal sepsis

Journal of Perinatology volume 41, pages 460–467 (2021)Cite this article

Subjects

Abstract

Objective

Infants born to mothers with preeclampsia are at risk for many short and long-term complications. The objective of this study was to examine the association between preeclampsia and ICD diagnosis of neonatal sepsis in a large United States data set.

Study design

A retrospective cohort study from the Consortium on Safe Labor. A total of 180,277 women with a singleton gestation greater than 23 weeks were included. The primary outcome, neonatal sepsis, was compared between women stratified by diagnosis of preeclampsia using univariable and multivariable analyses.

Results

Of the 180,277 women eligible for analysis, 8331 (4.6%) were diagnosed with preeclampsia. Neonatal sepsis rates were higher among women diagnosed with preeclampsia (6.4 vs. 2.0%, p < 0.001). In multivariable logistic regression, adjusted for confounders, the association between preeclampsia and neonatal sepsis remained significant (adjusted OR = 1.30, 95% CI: 1.06–1.60).

Conclusion

In this large cohort, the rate of neonatal sepsis ICD diagnosis was higher among women diagnosed with preeclampsia.

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Acknowledgements

We would like to acknowledge the NICHD for use of their database.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA

    Rachel K. Harrison & Anna Palatnik MD

  2. Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI, USA

    Anna Palatnik MD

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  1. Rachel K. Harrison
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Contributions

RKH contributed to the design, analysis, and interpretation of the data as well as drafting the work. AP contributed to the design, analysis, and interpretation of the data as well as revising the work. All authors approved the final version to be published and agree to be accountable for all aspects of the work.

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Correspondence to Rachel K. Harrison.

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Harrison, R.K., Palatnik, A. The association between preeclampsia and ICD diagnosis of neonatal sepsis. J Perinatol 41, 460–467 (2021). https://doi.org/10.1038/s41372-020-00774-0

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