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Delivery timing after laser surgery for twin-twin transfusion syndrome

Journal of Perinatology volume 40, pages 248–255 (2020)Cite this article

Subjects

Abstract

Objective

To compare outcomes of twin-twin transfusion syndrome (TTTS) patients who underwent early elective delivery vs. expectant management.

Study design

Retrospective study of monochorionic diamniotic twins who underwent laser surgery for TTTS and had dual survivors at 32 weeks. Patients who underwent elective delivery between 32 0/7 to 35 6/7 weeks (“early elective group”) were compared with all patients who delivered ≥36 0/7 weeks (“expectant management group”). The primary outcome was a composite of fetal and neonatal morbidity.

Results

The final study population was comprised of 15 early elective and 119 expectant management patients. Those in the early elective group were seven times more likely to experience the primary outcome (OR 7.38 [2.01–27.13], p = 0.0026).

Conclusion

Among patients who underwent laser surgery for TTTS who had dual survivors at 32 weeks, elective delivery prior to 36 weeks did not appear to be protective.

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Author information

Authors and Affiliations

  1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90007, United States

    Andrew H. Chon, Hikmat R. Chmait & Ramen H. Chmait

  2. Division of Neonatology, Department of Pediatrics, LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90007, United States

    Millie R. Chang

  3. Childbirth Research Associates, North Hollywood, CA, United States

    Lisa M. Korst

  4. Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90007, United States

    Philippe S. Friedlich

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  1. Andrew H. Chon
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Correspondence to Ramen H. Chmait.

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Portions of this manuscript were presented in Abstract # 220 Poster Session I at the Society for Maternal-Fetal Medicine 38th Annual Pregnancy Meeting, Dallas, Texas from January 29—February 3, 2018.

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Chon, A.H., Chang, M.R., Chmait, H.R. et al. Delivery timing after laser surgery for twin-twin transfusion syndrome. J Perinatol 40, 248–255 (2020). https://doi.org/10.1038/s41372-019-0532-5

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