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Survival trends and outcomes among preterm infants with congenital diaphragmatic hernia

Journal of Perinatology volume 40, pages 263–268 (2020)Cite this article

Subjects

Abstract

Objective

The objective of this study was to use current national data to evaluate the characteristics and survival trends of preterm infants born with CDH from 2004 to 2014.

Study design

Data was queried from the National Inpatient Sample (NIS) and KID database from 2004 to 2014. Infants were included if diagnosed with CDH by ICD-9 coding and gestational age <37 weeks. Descriptive statistics, chi-square, and trend analysis were completed.

Results

We identified 2356 infants born prematurely with CDH. The overall survival rate was 49%. The survival range is 21.2–62.3% for gestational age <26 weeks to 35–36 weeks, respectively. Total mortality was 1183; of them, 1052 (89%) were not repaired and 363 (30.7%) did not receive mechanical ventilation. Surgical repair occurred in 55.1% of infants.

Conclusions

Preterm infants have lower survival compared with term infants. Survival rates decrease with lower gestational age and have improved over time.

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Authors and Affiliations

  1. Department of Neonatology, Cleveland Clinic Children’s Hospital, Cleveland, OH, USA

    Allison M. Peluso, Hasan F. Othman, Esraa M. Elsamny, Ibrahim Sammour, Natalie K. Yeaney & Hany Aly

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  1. Allison M. Peluso
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  2. Hasan F. Othman
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  3. Esraa M. Elsamny
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  4. Ibrahim Sammour
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  5. Natalie K. Yeaney
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  6. Hany Aly
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Contributions

AP: conceptualized the study, and drafted and reviewed the manuscript. HO: carried out the initial analyses, and reviewed and revised the manuscript. IS: reviewed and revised the manuscript. EE: reviewed and revised the manuscript. NY: contributed expertize content and critically reviewed the manuscript. HA: conceptualized and designed the study and critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Correspondence to Allison M. Peluso.

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The authors declare that they have no conflict of interest.

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Peluso, A.M., Othman, H.F., Elsamny, E.M. et al. Survival trends and outcomes among preterm infants with congenital diaphragmatic hernia. J Perinatol 40, 263–268 (2020). https://doi.org/10.1038/s41372-019-0523-6

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  • DOI: https://doi.org/10.1038/s41372-019-0523-6

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