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The accuracy of transcutaneous bilirubinometry in preterm infants

Abstract

Objective

To evaluate the correlation between total serum and transcutaneous bilirubin and to determine the reliability of transcutaneous bilirubinometry for screening and monitoring of neonatal jaundice among preterms.

Study Design

Ninety nine infants with gestational ages ≤34 weeks were prospectively enrolled. Babies were classified into three groups as; 24–28, 29–31, and 32–34 weeks. Total serum bilirubin and simultaneous transcutaneous bilirubin were measured before the onset of phototheraphy, during and at 24 h after discontinuing phototherapy.

Results

Total serum bilirubin significantly correlated with transcutaneous bilirubin in the whole cohort (r = 0.867, p < 0.001) and in each group before, during and after phototheraphy. Hypotension was the only variable which effects the difference between two methods at postnatal first day of life (p = 0.039).

Conclusion

Transcutaneous bilirubin levels were highly correlated with total serum bilirubin levels even in 24–28 GW babies. Transcutaneous bilirubin may be useful for screening and monitoring of jaundice in very preterm newborns.

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References

  1. National Institute for Health and Clinical Excellence. Neonatal Jaundice. National Institute for Health and Clinical Excellence, 2010, www.nice.org.uk.

  2. Bhutani VK, Stark AR, Lazzeroni LC, Poland R, Gourley GR, Kazmierczak S, et al. Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy. J Pediatr. 2013;162:477–82.

    Article  Google Scholar 

  3. Maisels MJ, Kring E. Transcutaneous bilirubinometry decreases the need for serum bilirubin measurements and saves money. Pediatrics. 1997;99:599–601.

    Article  CAS  Google Scholar 

  4. De Luca D, Zecca E, de Turris P, Barbato G, Marras M, Romagnoli C. Using BiliCheck for preterm neonates in a subintensive unit: diagnostic usefulness and suitability. Early Hum Dev. 2007;83:313–7.

    Article  Google Scholar 

  5. Bhutani VK, Gourley GR, Adler S, Kreamer B, Dalin C, Johnson LH. Noninvasive measurement of total serum bilirubin in a multiracial predischarge newborn population to assess the risk of severe hyperbilirubinemia. Pediatrics. 2000;106:17.

    Article  Google Scholar 

  6. American Academy of Pediatrics, Subcommittee on Hyperbilirubinemia. Clinical guideline: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114:297–316.

    Article  Google Scholar 

  7. Schmidt ET, Wheeler CA, Jackson GL, Engle WD. Evaluation of transcutaneous bilirubinometry in preterm neonates. J Perinatol. 2009;29:564–9.

    Article  CAS  Google Scholar 

  8. Rubaltelli FF, Gourley GR, Loskamp N, Modi N, Roth-Kleiner M, Sender A, et al. Transcutaneous bilirubin measurement: a multicenter evaluation of a new device. Pediatrics. 2001;107:1264–71.

    Article  CAS  Google Scholar 

  9. Fonseca R, Kyralessa R, Malloy M, Richardson J, Jain SK. Covered skin transcutaneous bilirubin estimation is comparable with serum bilirubin during and after phototherapy. J Perinatol. 2012;32:129–31.

    Article  CAS  Google Scholar 

  10. Tan KL, Dong F. Transcutaneous bilirubinometry during and after phototherapy. Acta Paediatr. 2003;92:327–31.

    Article  CAS  Google Scholar 

  11. Ozkan H, Oren H, Duman N, Duman M. Dermal bilirubin kinetics during phototherapy in term neonates. Acta Paediatr. 2003;92:577–81.

    Article  CAS  Google Scholar 

  12. Hegyi T, Hiatt IM, Gertner IM, Zanni R, Tolentino T. Transcutaneous bilirubinometry II. Dermal bilirubin kinetics during phototherapy. Pediatr Res. 1983;17:888–91.

    Article  CAS  Google Scholar 

  13. Nanjundaswamy S, Petrova A, Mehta R, Hegyi T. Transcutaneous bilirubinometry in preterm infants receiving phototherapy. Am J Perinatol. 2005;22:127–31.

    Article  Google Scholar 

  14. Knupfer M, Pulzer F, Braun L, Heilmann A, Robel-Tillig E, Vogtmann C. Transcutaneous bilirubinometry in preterm infants. Acta Paediatr. 2001;90:899–903.

    Article  CAS  Google Scholar 

  15. Tan KL, Mylvaganam A. Transcutaneous bilirubinometry in preterm very low birthweight infants. Acta Paediatr Scand. 1988;77:796–801.

    Article  CAS  Google Scholar 

  16. Nagar G, Vandermeer B, Campbell S, Kumar M. Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review. Pediatrics. 2013;132:871–81.

    Article  Google Scholar 

  17. Rubio A, Epiard C, Gebus M, Deiber M, Samperiz S, Genty C, et al. Diagnosis accuracy of transcutaneous bilirubinometry in very preterm newborns. Neonatology. 2017;111:1–7.

    Article  CAS  Google Scholar 

  18. Maisels MJ. Transcutaneous bilirubinometry. Neo Rev. 2006;7:217–25.

    Google Scholar 

  19. Pendse A, Jasani B, Nanavati R, Kabra N. Comparison of transcutaneous bilirubin measurement with total serum bilirubin levels in preterm neonates receiving phototherapy. Indian Pediatr. 2017;54:641–3.

    Article  Google Scholar 

  20. Jangaard KA, Curtis H, Goldbloom RB. Estimation of bilirubin using BiliChek, a transcutaneous bilirubin measurement device: effects of gestational age and use of phototherapy. Paediatr Child Health. 2006;11:79–83.

    Article  Google Scholar 

  21. Zecca E, Barone G, De Luca D, Marra R, Tiberi E, Romagnoli C. Skin bilirubin measurement during phototherapy in preterm and term newborn infants. Early Hum Dev. 2009;85:537–40.

    Article  CAS  Google Scholar 

  22. Maisels MJ, Coffey MP, Kring E. Transcutaneous bilirubin levels in newborns <35 weeks’ gestation. J Perinatol. 2015;35:739–44.

    Article  CAS  Google Scholar 

  23. Willems WA, van den Berg LM, de Wit H, Molendijk A. Transcutaneous bilirubinometry with the BiliCheck in very premature newborns. J Matern Fetal Neonatal Med. 2004;16:209–14.

    Article  CAS  Google Scholar 

  24. Bosschaart N, Kok JH, Newsum AM, Ouweneel DM, Mentink R, van Leeuwen TG, et al. Limitations and opportunities of transcutaneous bilirubin measurements. Pediatrics. 2012;129:689–94.

    Article  Google Scholar 

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Correspondence to Didem Arman.

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Arman, D., Topcuoğlu, S., Gürsoy, T. et al. The accuracy of transcutaneous bilirubinometry in preterm infants. J Perinatol 40, 212–218 (2020). https://doi.org/10.1038/s41372-019-0445-3

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