Abstract
Objective
To evaluate the relationship between prenatal and postnatal inflammation-related risk factors and severe retinopathy of prematurity (ROP).
Study design
The study included infants born <30 weeks in California from 2007 to 2011. Multivariable log-binomial regression was used to assess the association between prenatal and postnatal inflammation-related exposures and severe ROP, defined as stage 3ā5 or surgery for ROP.
Results
Of 14,816 infants, 10.8% developed severe ROP. Though prenatal inflammation-related risk factors were initially associated with severe ROP, after accounting for the effect of these risk factors on gestational age at birth through mediation analysis, the association was non-significant (Pā=ā0.6). Postnatal factors associated with severe ROP included prolonged oxygen exposure, sepsis, intraventricular hemorrhage, and necrotizing enterocolitis.
Conclusion
Postnatal inflammation-related factors were associated with severe ROP more strongly than prenatal factors. The association between prenatal inflammation-related factors and ROP was explained by earlier gestational age in infants exposed to prenatal inflammation.
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Acknowledgements
G.P.G. is supported in part by the Stanford Maternal & Child Health Research Institute. S.A.L. is supported in part by postdoctoral fellowship F32HD091945 from the Eunice Kennedy Shriver National Institute of Child Health and Development and a postdoctoral fellowship from the Stanford Maternal & Child Health Research Institute.
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Goldstein, G.P., Leonard, S.A., Kan, P. et al. Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity. J Perinatol 39, 964ā973 (2019). https://doi.org/10.1038/s41372-019-0357-2
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DOI: https://doi.org/10.1038/s41372-019-0357-2
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