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Can mixed lipid emulsion prevent parenteral nutrition associated cholestasis?

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References

  1. Salvador A, Janeczko M, Porat R, Sekhon R, Moewes A, Schutzman D. Randomized controlled trial of early parenteral nutrition cycling to prevent cholestasis in very low birth weight infants. J Pediatr. 2012;161:229–33 e1.

    Article  Google Scholar 

  2. Hsieh MH, Pai W, Tseng HI, Yang SN, Lu CC, Chen HL. Parenteral nutrition-associated cholestasis in premature babies: risk factors and predictors. Pediatr Neonatol. 2009;50:202–7.

    Article  Google Scholar 

  3. Park HW, Lee NM, Kim JH, Kim KS, Kim SN. Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr. 2015;145:277–83.

    Article  Google Scholar 

  4. Premkumar MH, Carter BA, Hawthorne KM, King K, Abrams SA. High rates of resolution of cholestasis in parenteral nutrition-associated liver disease with fish oil-based lipid emulsion monotherapy. J Pediatr. 2013;162:793–8 e1.

    Article  CAS  Google Scholar 

  5. Sorrell M, Moreira A, Green K, Jacob R, Tragus R, Keller L, et al. Favorable outcomes of preterm infants with parenteral nutrition-associated liver disease treated with intravenous fish oil-based lipid emulsion. J Pediatr Gastroenterol Nutr. 2017;64:783–8.

    Article  CAS  Google Scholar 

  6. Lam HS, Tam YH, Poon TC, Cheung HM, Yu X, Chan BP, et al. A double-blind randomised controlled trial of fish oil-based versus soy-based lipid preparations in the treatment of infants with parenteral nutrition-associated cholestasis. Neonatology. 2014;105:290–6.

    Article  CAS  Google Scholar 

  7. Repa A, Lochmann R, Unterasinger L, Weber M, Berger A, Haiden N. Aggressive nutrition in extremely low birth weight infants: impact on parenteral nutrition associated cholestasis and growth. PeerJ. 2016;4:e2483.

    Article  Google Scholar 

  8. Kapoor V, Glover R, Malviya MN. Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants. Cochrane Database Syst Rev. 2015:CD009172.

  9. Bourke GJ, Daly LE, McGilvray J. Interpretation and Uses of Medical Statistics, 3rd Ed. London, England: Blackwell Scientific Publications; 1985.

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Acknowledgements

The Journal Club is a collaboration between the American Academy of Pediatrics - Section of Neonatal Perinatal Medicine and the International Society for Evidence-Based Neonatology (EBNEO.org)

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Correspondence to Kate A. Tauber.

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Tauber, K., Clark, D. Can mixed lipid emulsion prevent parenteral nutrition associated cholestasis?. J Perinatol 39, 593–595 (2019). https://doi.org/10.1038/s41372-018-0270-0

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