To identify the vitamin D status to optimize calcium and bone health in preterm infants.
Very low birth weight infants had measurement of 25-hydroxyvitamin D status and markers of calcium and bone health from birth to term age. Piecewise linear regression modeling was performed to identify a 25-hydroxyvitamin D threshold associated with stable parathyroid hormone concentration and bone mineralization.
In a cohort of 89 infants at term age, femur BMC and density increased linearly with 25-hydroxyvitamin D status until reaching a threshold of 48 ng/mL and 46 ng/mL, respectively. Parathyroid hormone status decreased as vitamin D status increased until reaching a plateau at 25-hydroxyvitamin D of 42 ng/mL.
Preterm infant vitamin D status was significantly associated with PTH status and femur mineralization with suggestion that achieving a specific 25-hydroxyvitamin concentration is associated with optimal calcium homeostasis and femur bone mineralization.
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NIH/NCRR (K23 RR021891) and National Institutes of Health (NIH) Clinical and Translational Science Award (CTSA) program, grant (UL1TR001450).
Conflict of interest
The authors declare that they have no conflict of interest.
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Taylor, S.N., Wahlquist, A., Wagner, C.L. et al. Functional indicators of vitamin D adequacy for very low birth weight infants. J Perinatol 38, 550–556 (2018). https://doi.org/10.1038/s41372-018-0098-7