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Precision therapeutics in the NICU: why are we missing the mark?

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References

  1. 1.

    Ward RM, Tammara B, Sullivan SE, Stewart DL, Rath N, Meng X, et al. Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD). Eur J Clin Pharmacol. 2010;66:555–61.

    CAS  Article  Google Scholar 

  2. 2.

    Allegaert K, van Schaik RH, Vermeersch S, Verbesselt R, Cossey V, Vanhole C, et al. Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Pediatr Res. 2008;63:674–9.

    CAS  Article  Google Scholar 

  3. 3.

    Zhu R, Kiser JJ, Seifart HI, Werely CJ, Mitchell CD, D’Argenio DZ, et al. The pharmacogenetics of NAT2 enzyme maturation in perinatally HIV exposed infants receiving isoniazid. J Clin Pharmacol. 2012;52:511–9.

    CAS  Article  Google Scholar 

  4. 4.

    Matic M, Simons SH, van Lingen RA, van Rosmalen J, Elens L, de Wildt SN, et al. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Pharmacogenomics. 2014;15:1287–95.

    CAS  Article  Google Scholar 

  5. 5.

    Turner MA, Davis JM, McCune S, Bax R, Portman RJ, Hudson LD. The International Neonatal Consortium: collaborating to advance regulatory science for neonates. Pediatr Res. 2016;80:462–4.

    CAS  Article  Google Scholar 

  6. 6.

    Lewis T, Dinh J, Leeder JS. Genetic determinants of fetal opiate exposure and risk of neonatal abstinence syndrome: knowledge deficits and prospects for future research. Clin Pharmacol Ther. 2015;98:309–20.

    CAS  Article  Google Scholar 

  7. 7.

    Giudici V, Pogliani L, Cattaneo D, Dilillo D, Zuccotti GV. Serotonin reuptake inhibitors in pregnancy: can genes help us in predicting neonatal adverse outcome? BioMed Res Int. 2014;2014:276918.

    Article  Google Scholar 

  8. 8.

    Ounissi M, Benkirane A, Dempsey E, Soares R, Jullien V, Pons G, et al. A review of potential pharmacogenetic effects on catecholamine responses. Drug Metab Rev. 2015;47:558–64.

    CAS  Article  Google Scholar 

Download references

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TL conceptualized the article, performed necessary lit review, designed the table and figures, and wrote the manuscript.

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Correspondence to Tamorah Lewis.

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Lewis, T. Precision therapeutics in the NICU: why are we missing the mark?. J Perinatol 38, 444–446 (2018). https://doi.org/10.1038/s41372-018-0052-8

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