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The influence of left ventricular geometry on myocardial work in essential hypertension

Journal of Human Hypertension volume 36, pages 524–530 (2022)Cite this article

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Abstract

We sought to investigate echocardiography-derived myocardial work in hypertensive patients with different left ventricular (LV) geometric patterns. This cross-sectional study included 211 hypertensive patients (74 with normal LV geometry, 53 with concentric remodeling, 46 with eccentric LV hypertrophy (LVH) and 38 with concentric LVH) who underwent complete two-dimensional echocardiographic examination including two-dimensional speckle-tracking echocardiography. Pressure-strain curve was used to determine parameters of myocardial work. Our findings showed that multidirectional LV strain was lower in patients with eccentric and concentric LVH than in those with normal LV geometry and concentric remodeling. Global myocardial work index and global constructive work were higher in patients with eccentric and concentric LVH than in those with normal LV geometry and concentric remodeling. Global wasted work and global efficacy work were similar between groups with different LV geometry. E/e’ and LV mass index were associated with global myocardial work index and global constructive work independently of clinical and echocardiographic parameters. In conclusion, myocardial work was higher in patients with eccentric and concentric LVH than in patients with normal LV geometry and concentric remodeling. Increased blood pressure in patients with concentric LVH in comparison with other LV geometric patterns has significant impact on the final result. LV geometry has significant impact on myocardial work in hypertensive patients.

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Authors and Affiliations

  1. Department of Cardiology, University Hospital “Dr. Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, 11000, Belgrade, Serbia

    Marijana Tadic, Jelena Suzic Lazic, Vladan Vukomanovic & Vera Celic

  2. Department of Medicine and Surgery, University Milano-Bicocca, Milano, Italy

    Cesare Cuspidi & Guido Grassi

  3. Istituto Auxologico Italiano IRCCS, Clinical Research Unit, Via Pace 18, 20036, Meda, Italy

    Cesare Cuspidi

  4. Department of Heart Disease, Haukeland University Hospital, Bergen, Norway

    Sahrai Saeed

  5. Department of Clinical Sciences and Community Health, University of Milano and Fondazione Ospedale Maggiore IRCCS Policlinico di Milano, Milano, Italy

    Carla Sala

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  1. Marijana Tadic
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  2. Cesare Cuspidi
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  3. Sahrai Saeed
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  4. Jelena Suzic Lazic
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  5. Vladan Vukomanovic
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  6. Guido Grassi
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  7. Carla Sala
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  8. Vera Celic
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Correspondence to Marijana Tadic.

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Tadic, M., Cuspidi, C., Saeed, S. et al. The influence of left ventricular geometry on myocardial work in essential hypertension. J Hum Hypertens 36, 524–530 (2022). https://doi.org/10.1038/s41371-021-00543-2

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