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The prevalence and predictors of pre-hypertension and hypertension in Kherameh cohort study: a population based study on 10,663 persons in south of Iran

Journal of Human Hypertension volume 35, pages 257–264 (2021)Cite this article

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Abstract

Hypertension (HTN) is an important risk factor for cardiovascular disease (CVD) mortality and morbidity among Iranians. The present study aimed to estimate the prevalence of pre-HTN and HTN and some of its related factors in south of Iran. This cross-sectional survey was conducted on the data of the Persian cohort study in Kherameh. The participants consisted of 10,663 people aged 40–70 years. HTN was defined as either systolic/diastolic blood pressure (SBP/DBP) ≥140/90 mmHg or taking medications. Pre-HTN was defined as SBP = 120–139 mmHg and/or DBP = 80–89 mmHg. The logistic regression method was used to identify the factors associated with pre-HTN and HTN. The age-standardized prevalence rate (ASPR) of pre-HTN was 19.66% (95% CI: 19.45–19.86%) and 18.59% (95% CI: 18.36–18.83%) in males and females, respectively. Also, the ASPR of HTN was 21.44 (95% CI: 21.22–21.65%) in males and 33.53% (95% CI: 33.22–33.85%) in females. Male gender, old age, being unemployed, low education level, high body mass index (BMI), no smoking, diabetes, cerebro-cardiovascular disease, suffering from another chronic disease, family history of CVD, and negative family history of cancer and other chronic diseases were independently associated with pre-HTN (p < 0.05). All variables, except for gender, smoking, and family history of cancer, were significantly associated with HTN. Drug abuse was also correlated to HTN (p < 0.05). This study revealed the increased prevalence of HTN in rural and urban areas. Therefore, the health system needs to develop strategies to raise the accessibility of screening and diagnostic services.

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References

  1. Zinat Motlagh SF, Chaman R, Ghafari SR, Parisay Z, Golabi MR, Eslami AA, et al. Knowledge, treatment, control, and risk factors for hypertension among adults in Southern Iran. Int J Hypertension. 2015. https://doi.org/10.1155/2015/897070.

  2. Sepanlou SG, Kamangar F, Poustchi H, Malekzadeh R. Reducing the burden of chronic diseases: a neglected agenda in Iranian health care system, requiring a plan for action. Arch Iran Med. 2010;13:340–50.

    PubMed  Google Scholar 

  3. Wang J, Sun W, Wells GA, Li Z, Li T, Wu J, et al. Differences in prevalence of hypertension and associated risk factors in urban and rural residents of the northeastern region of the People’s Republic of China: a cross-sectional study. PLoS ONE 2018;13:e0195340.

    PubMed  PubMed Central  Google Scholar 

  4. Belachew A, Tewabe T, Miskir Y, Melese E, Wubet E, Alemu S, et al. Prevalence and associated factors of hypertension among adult patients in Felege–Hiwot Comprehensive Referral Hospitals, northwest, Ethiopia: a cross-sectional study. BMC Res Notes. 2018;11:876.

    PubMed  PubMed Central  Google Scholar 

  5. Danaei G, Finucane MM, Lin JK, Singh GM, Paciorek CJ, Cowan MJ, et al. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5· 4 million participants. Lancet 2011;377:568–77.

    PubMed  Google Scholar 

  6. Eghbali M, Khosravi A, Feizi A, Mansouri A, Mahaki B, Sarrafzadegan N. Prevalence, awareness, treatment, control, and risk factors of hypertension among adults: a cross-sectional study in Iran. Epidemiol Health. 2018;40:e2018020.

    PubMed  PubMed Central  Google Scholar 

  7. Ebrahimi M, Mansournia MA, Haghdoost AA, Abazari A, Alaeddini F, Mirzazadeh A, et al. Social disparities in prevalence, treatment and control of hypertension in Iran: second National Surveillance of Risk Factors of Noncommunicable Diseases, 2006. J Hypertens. 2010;28:1620–9.

    CAS  PubMed  Google Scholar 

  8. Ghaffari S, Pourafkari L, Tajlil A, Sahebihagh MH, Mohammadpoorasl A, Tabrizi JS, et al. The prevalence, awareness and control rate of hypertension among elderly in northwest of Iran. J Cardiovasc Thorac Res. 2016;8:176–82.

    PubMed  PubMed Central  Google Scholar 

  9. Khosravi A, Emamian MH, Shariati M, Hashemi H, Fotouhi A. The prevalence of pre-hypertension and hypertension in an Iranian urban population. High Blood Press Cardiovasc Prev. 2014;21:127–35.

    PubMed  Google Scholar 

  10. Kowlessur S, Hu Z, Heecharan J, Wang J, Dai J, Tuomilehto JO, et al. Predictors of hypertension in mauritians with normotension and prehypertension at baseline: a Cohort Study. Int J Environ Res Public Health. 2018;15:1394.

    PubMed Central  Google Scholar 

  11. Mittal BV, Singh AK. Hypertension in the developing world: challenges and opportunities. Am J Kidney Dis. 2010;55:590–8.

    PubMed  Google Scholar 

  12. Aldiab A, Shubair MM, Al-Zahrani JM, Aldossari KK, Al-Ghamdi S, Househ M, et al. Prevalence of hypertension and prehypertension and its associated cardioembolic risk factors; a population based cross-sectional study in Alkharj, Saudi Arabia. BMC Public Health. 2018;18:1327.

    PubMed  PubMed Central  Google Scholar 

  13. Krishnan A, Garg R, Kahandaliyanage A, editors. Hypertension in the South-East Asia region: an overview. Regional Health Forum; 2013.

  14. Abebe SM, Berhane Y, Worku A, Getachew A. Prevalence and associated factors of hypertension: a crossectional community based study in Northwest Ethiopia. PLoS ONE 2015;10:e0125210.

    PubMed  PubMed Central  Google Scholar 

  15. Kheradmand M, Enayati A, Rafiei A, Moosazadeh M. Population based cohort studies in Iran: a review article. J Mazandaran Univ Med Sci. 2015;25:171–85.

    Google Scholar 

  16. Poustchi H, Eghtesad S, Kamangar F, Etemadi A, Keshtkar A-A, Hekmatdoost A, et al. Prospective Epidemiological Research Studies in Iran (the PERSIAN Cohort Study): rationale, objectives, and design. Am J Epidemiol. 2018;187:647–55.

    PubMed  Google Scholar 

  17. Shahbazian H, Latifi SM, Jalali MT, Shahbazian H, Amani R, Nikhoo A, et al. Metabolic syndrome and its correlated factors in an urban population in South West of Iran. J Diabetes Metab Disord. 2013;12:11.

    PubMed  PubMed Central  Google Scholar 

  18. Organization WHO. Global database on Body Mass Index: BMI Classification, 2006. Geneva, Switzerland: World Health Organization; 2015.

    Google Scholar 

  19. Gupta R, Deedwania PC, Achari V, Bhansali A, Gupta BK, Gupta A, et al. Normotension, prehypertension, and hypertension in urban middle-class subjects in India: prevalence, awareness, treatment, and control. Am J Hypertens. 2012;26:83–94.

    Google Scholar 

  20. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J 2018;39:3021–104.

    Google Scholar 

  21. Sankoh O, Sharrow D, Herbst K, Whiteson Kabudula C, Alam N, Kant S, et al. The INDEPTH standard population for low-and middle-income countries, 2013. Glob Health Action. 2014;7:23286.

    PubMed  Google Scholar 

  22. Barengo N, Antikainen R, Kastarinen M, Laatikainen T, Tuomilehto J. The effects of control of systolic and diastolic hypertension on cardiovascular and all-cause mortality in a community-based population cohort. J Hum Hypertens. 2013;27:693–97.

    CAS  PubMed  Google Scholar 

  23. Hu L, Huang X, You C, Li J, Hong K, Li P, et al. Prevalence and risk factors of prehypertension and hypertension in Southern China. PLoS ONE 2017;12:e0170238.

    PubMed  PubMed Central  Google Scholar 

  24. Rani B, Pal R, Jha S, Punia A, Singh S. Prevalence and risk factors associated with prehypertension and hypertension among attendants of patients at a rural tertiary care institute of Haryana. Int J Community Med Public Health. 2019;6:1657–64.

    Google Scholar 

  25. Taherian R, Jalali-Farahani S, Karimi M, Amiri P, Maghsoudi E, Mirmiran P, et al. Factors associated with pre-hypertension among Tehranian adults: a novel application of structural equation models. Int J Endocrinol Metab. 2018;16:e59706.

  26. Singh M, Kotwal A, Mittal C, Babu SR, Bharti S, Ram CVS. Prevalence and correlates of hypertension in a semi-rural population of Southern India. J Hum Hypertens. 2018;32:66–74.

    Google Scholar 

  27. Peymani P, Heydari ST, Ahmadi SM, Sarikhani Y, Joulaei H, Moghadami M, et al. The prevalence of high blood pressure and its relationship with anthropometric indicators; a population based study in Fars Province, IR Iran. Int Cardiovasc Res J. 2012;6:40–5.

    Google Scholar 

  28. Malekzadeh MM, Etemadi A, Kamangar F, Khademi H, Golozar A, Islami F, et al. Prevalence, awareness and risk factors of hypertension in a large cohort of Iranian adult population. J Hypertens. 2013;31:1364.

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Katibeh M, Sanjari Moghaddam A, Yaseri M, Neupane D, Kallestrup P, Ahmadieh H. Hypertension and associated factors in the Islamic Republic of Iran: a population-based study. East Mediterr Health J. 2019;25.

  30. Pakzad B, Akbari M, Baberi F. Prevalence, awareness, treatment, and control of hypertension in an Isfahan State Institution Sample. J Tehran Univ Heart Cent. 2018;13:65–72.

    Google Scholar 

  31. Yang G, Ma Y, Wang S, Su Y, Rao W, Fu Y, et al. Prevalence and correlates of prehypertension and hypertension among adults in Northeastern China: a cross-sectional study. Int J Environ Res Public Health. 2016;13:82.

    Google Scholar 

  32. Gandomkar A, Poustchi H, Malekzadeh F, Malekzadeh MM, Moini M, Moghadami M, et al. Prevalence, awareness, treatment, control, and correlates of hypertension in the Pars Cohort Study. Arch Iran Med. 2018;21:335–43.

    PubMed  Google Scholar 

  33. Nuwaha F, Musinguzi G. Pre-hypertension in Uganda: a cross-sectional study. BMC Cardiovasc Disord. 2013;13:101.

    PubMed  PubMed Central  Google Scholar 

  34. Lam CS, Cheng S, Choong K, Larson MG, Murabito JM, Newton-Cheh C, et al. Influence of sex and hormone status on circulating natriuretic peptides. J Am Coll Cardiol. 2011;58:618–26.

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Tian S, Dong G-H, Wang D, Liu M-M, Lin Q, Meng X-J, et al. Factors associated with prevalence, awareness, treatment and control of hypertension in urban adults from 33 communities in China: the CHPSNE Study. Hypertens Res 2011;34:1087.

    PubMed  Google Scholar 

  36. Vasan RS, Beiser A, Seshadri S, Larson MG, Kannel WB, D’Agostino RB, et al. Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA 2002;287:1003–10.

    PubMed  Google Scholar 

  37. JSDd Costa, Barcellos FC, Sclowitz ML, Sclowitz IKT, Castanheira M, Olinto MTA, et al. Hypertension prevalence and its associated risk factors in adults: a population-based study in Pelotas. Arquivos Bras Cardiol. 2007;88:54–9.

    Google Scholar 

  38. Basu S, Millett C. Social epidemiology of hypertension in middle-income countries: determinants of prevalence, diagnosis, treatment, and control in the WHO SAGE study. Hypertension 2013;62:18–26.

    CAS  PubMed  Google Scholar 

  39. Kumar J, Deshmukh PR, Garg BS. Prevalence and correlates of sustained hypertension in adolescents of rural Wardha, central India. Indian J Pediatr. 2012;79:1206–12.

    PubMed  Google Scholar 

  40. Leng B, Jin Y, Li G, Chen L, Jin N. Socioeconomic status and hypertension: a meta-analysis. J Hypertens. 2015;33:221–9.

    CAS  PubMed  Google Scholar 

  41. Cha SH, Park HS, Cho HJ. Socioeconomic disparities in prevalence, treatment, and control of hypertension in middle-aged Koreans. J Epidemiol. 2012;22:425–32.

    PubMed  PubMed Central  Google Scholar 

  42. Huang J, Zhang W, Li X, Zhou J, Gao Y, Cai Y, et al. Analysis of the prevalence and risk factors of hypertension in the She population in Fujian, China. Kidney Blood Press Res. 2011;34:69–74.

    CAS  PubMed  Google Scholar 

  43. Cutler DM, Lleras-Muney A. Understanding differences in health behaviors by education. J Health Econ. 2010;29:1–28.

    PubMed  Google Scholar 

  44. El Bcheraoui C, Memish ZA, Tuffaha M, Daoud F, Robinson M, Jaber S, et al. Hypertension and its associated risk factors in the kingdom of saudi arabia, 2013: a national survey. Int J Hypertens. 2014. https://doi.org/10.1155/2014/564679.

  45. Jatoi NA, Jerrard-Dunne P, Feely J, Mahmud A. Impact of smoking and smoking cessation on arterial stiffness and aortic wave reflection in hypertension. Hypertension 2007;49:981–5.

    CAS  PubMed  Google Scholar 

  46. Panesar S, Chaturvedi S, Saini N, Avasthi R, Singh A. Prevalence and predictors of hypertension among residents aged 20–59 years of a slum-resettlement colony in Delhi, India. WHO South-East Asia J Public Health. 2013;2:83–7.

    PubMed  Google Scholar 

  47. Simonetti GD, Schwertz R, Klett M, Hoffmann GF, Schaefer F, Wühl E. Determinants of blood pressure in preschool children: the role of parental smoking. Circulation 2011;123:292–8.

    PubMed  Google Scholar 

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Acknowledgements

The authors would like to thank Ms. A. Keivanshekouh at the Research Improvement Center of Shiraz University of Medical Sciences for improving the use of English in the manuscript.

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Authors and Affiliations

  1. Colorectal Research Center, SUMS, Shiraz, Iran

    Abbas Rezaianzadeh & Salar Rahimikazerooni

  2. MSc Candidate of Epidemiology in Shiraz University of Medical Sciences, Shiraz, Iran

    Fatemeh Jafari

  3. Anesthesiology Department, SUMS, Shiraz, Iran

    Seyed Ebrahim Sadeghi

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Correspondence to Fatemeh Jafari.

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Rezaianzadeh, A., Jafari, F., Sadeghi, S.E. et al. The prevalence and predictors of pre-hypertension and hypertension in Kherameh cohort study: a population based study on 10,663 persons in south of Iran. J Hum Hypertens 35, 257–264 (2021). https://doi.org/10.1038/s41371-020-0330-8

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