Scientific statement

Hydrochlorothiazide and the risk of skin cancer. A scientific statement of the British and Irish Hypertension Society

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  1. 1.

    Thomopoulos C, Parati G, Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 4. Effects of various classes of antihypertensive drugs—overview and meta-analyses. J Hypertens. 2015;33:195–211.

  2. 2.

    Pottegård A, Hallas J, Olesen M, Svendsen MT, Habel LA, Friedman GD, et al. Hydrochlorothiazide use is strongly associated with risk of lip cancer. J Intern Med. 2017;282:322–31.

  3. 3.

    Pedersen SA, Gaist D, Schmidt SAJ, Hölmich LR, Friis S, Pottegård A. Hydrochlorothiazide use and risk of non melanoma skin cancer: a nationwide case-control study from Denmark. J Am Acad Dermatol. 2018;78:673–81.e9.

  4. 4.

    Pottegård A, Pedersen SA, Schmidt SAJ, Hölmich LR, Friis S, Gaist D. Association of hydrochlorothiazide use and risk of malignant melanoma. JAMA Intern Med. 2018;178:1120–2.

  5. 5.

    Pedersen SA, Johannesdottir Schmidt SA, Hölmich LR, Friis S, Pottegård A, et al. Hydrochlorothiazide use and risk for Merkel cell carcinoma and malignant adnexal skin tumors: a nationwide case–control study. J Am Acad Dermatol. 2019;80:460–5.e9.

  6. 6.

    Cancer Research UK. Melanoma skin cancer statistics. Cancer Research UK, 2016.

  7. 7.

    Cancer Research UK. Non-melanoma skin cancer mortality statistics. Cancer Research UK, 2016.

  8. 8.

    International Agency for Research on Cancer (IARC). Some Drugs and Herbal products. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; 2016: vol. 108.

  9. 9.

    MHRA. Hydrochlorothiazide: risk of non-melanoma skin cancer, particularly in long-term use. ; 2018. Accessed February 12, 2019.

  10. 10.

    NICE. Hypertension in adults: diagnosis and management (CG127). ;2011. Accessed Feb 12, 2019.

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