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Electrocardiographic-left ventricular hypertrophy and incident stroke among Chinese hypertensive adults

Journal of Human Hypertension volume 34, pages 286–292 (2020)Cite this article

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Abstract

The relationship between electrocardiographic-left ventricular hypertrophy (ECG-LVH) and stroke has been well established in the Western population with limited information in the Chinese population. This study evaluated the association between ECG-LVH and stroke outcome. A total of 19,815 (95.7%) subjects from the China Stroke Primary Prevention Trial (CSPPT) with baseline ECG were included. ECG-LVH by sex-unspecific Sokolow-Lyon criteria was detected in 1599 participants (8.1%) at baseline. After a mean follow-up of 4.5 years, 605 (3.1%) subjects were detected with new-onset stroke over the total population, baseline ECG-LVH was present in 72 (4.5%) of them during follow-up. After adjusting for various cofounders, ECG-LVH remained as an independent risk factor for stroke events in the total population (HR = 1.43; 95% CI, 1.10–1.84; P = 0.007) and male population (HR = 1.47; 95% CI, 1.07–2.03; P = 0.019). Subgroup analysis showed that baseline ECG-LVH was a risk factor for stroke in individuals younger than 65 years of age(HR = 1.80, 95% CI, 1.31–2.47 vs. HR = 1.02, 95% CI, 0.66–1.59, P value for interaction = 0.047). In summary, LVH diagnosed by ECG is associated with an excess risk for stroke in Chinese hypertensive population, especially in the age group of younger than 65 years.

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Acknowledgements

The authors appreciate the participants who volunteered to participate in the study, and the data collection staff of the CSPPT team.

Funding

The study was supported by National Science and Technology Major Projects Specialized for “Precision Medicine Research” during the 13th Five-Year Plan Period (No. 2016YFC0903100); the State Key Program of National Natural Science Foundation of China (No. 81530015 to Y.G.L); Projects of National Natural Science Foundation of China (Nos. 81473052 and 81402735 to Y.G.L); the Science, Technology and Innovation Committee of Shenzhen (No. JCYL20130401162636527); the Department of Development and Reform, Shenzhen Municipal Government (No. SFG 20201744); the Special Project on the Integration of Industry, Education and Research of Guangdong Province (No. 2011A091000031); and the Science and Technology Planning Project of Guangdong Province, China (No. 2014B090904040).

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Authors and Affiliations

  1. Department of Cardiology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China

    Yan Zhao, Peng-Pai Zhang, Wei Li, Jun Wang, Quan-Fu Xu & Yi-Gang Li

  2. Department of Cardiovascular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China

    Xiao Huang, Huihui Bao & Xiaoshu Cheng

  3. National Clinical Research Study Center for Kidney Disease; State Key Laboratory for Organ Failure Research; Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Yaren Yu, Min Zhao, Rui Gu, Yu Wang, Binyan Wang & Xianhui Qin

  4. Department of Cardiology, Peking University First Hospital, Beijing, China

    Fangfang Fan, Jianping Li, Yan Zhang & Yong Huo

  5. School of Health Administration, Anhui University, Hefei, China

    Genfu Tang

  6. Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China

    Yefeng Cai

  7. Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China

    Qiang Dong

  8. Department of Cardiology, First People’s Hospital, Lianyungang, China

    Delu Yin

  9. Department of Neurology, First People’s Hospital, Lianyungang, China

    Mingli He

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  1. Yan Zhao
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  11. Fangfang Fan
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  15. Genfu Tang
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  16. Yefeng Cai
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  17. Qiang Dong
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  18. Delu Yin
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  19. Xiaoshu Cheng
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  20. Mingli He
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  22. Xianhui Qin
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  23. Yong Huo
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  24. Yi-Gang Li
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Correspondence to Yong Huo or Yi-Gang Li.

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Zhao, Y., Huang, X., Zhang, PP. et al. Electrocardiographic-left ventricular hypertrophy and incident stroke among Chinese hypertensive adults. J Hum Hypertens 34, 286–292 (2020). https://doi.org/10.1038/s41371-018-0155-x

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