The mechanisms by which neighborhood environmental exposures influence health are poorly understood, although immune system dysregulation represents a potential biological pathway. While many neighborhood exposures have been investigated, there is little research on residential proximity to brownfield waste. Using biomarker data from 262 participants in the Detroit Neighborhood Health Study, we estimated the association between proximity to brownfields and heavy traffic and signal joint T-cell receptor excision circles (sjTRECs, a measure of naive T-cell production), C-reactive protein (CRP, a measure of systemic inflammation), and interleukin-6 (IL-6, a pro-inflammatory cytokine). We assessed residential proximity ≤200 m from brownfields and highways on all three biomarkers using multivariate regression. We demonstrated that living ≤200 m from a brownfield site was associated with a 0.30 (95% CI = 0.59, 0.02, p = 0.04) loge-unit decrease in sjTRECs per million whole blood cells, as well as non-significantly elevated levels of CRP and IL-6. Heavy traffic was not associated with any biomarker. Persons living in close proximity to brownfield sites had significantly lower naive T-cell production, suggesting accelerated immune aging. Decreased T-cell production associated with brownfield proximity may be caused by toxicant exposure in brownfield sites, or may serve as a marker of other neighborhood stressors.
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The Detroit Neighborhood Health Study received funding from the National Institutes of Health (R01 DA022720, R01 MD011728). The University of Michigan Nathan Shock Center provided funding for IL-6 and CRP testing (AG013283). Lodge was supported by the University of North Carolina at Chapel Hill Medical Scientist Training Program (T32 GM008719–18), the National Institute of Environmental Health Sciences (T32 ES007018), the National Institute of Child Health and Human Development (T32 HD007168), and the University of North Carolina at Chapel Hill Graduate School Doctoral Merit Assistantship. Data Driven Detroit (https://datadrivendetroit.org) provided data on brownfield sites in Detroit obtained by the Michigan Department of Environmental Quality (MDEQ) in 2014 with the help of N. Urban.
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Lodge, E.K., Engel, L.S., Ferrando-Martínez, S. et al. The association between residential proximity to brownfield sites and high-traffic areas and measures of immunity. J Expo Sci Environ Epidemiol 30, 824–834 (2020). https://doi.org/10.1038/s41370-020-0226-2
- Population-based studies
- Personal exposure
- Exposure modeling
- Environmental monitoring