Article | Published:

Pediatrics

Associations of prenatal exposure to impaired glucose tolerance with eating in the absence of hunger in early adolescence

International Journal of Obesity (2019) | Download Citation

Abstract

Objective

Exposure to impaired gestational glucose tolerance has been shown to have sex-specific associations with offspring obesity risk, perhaps by affecting the development of appetite regulation. We examined the extent to which prenatal exposure to impaired glucose tolerance was associated with eating in the absence of hunger (EAH) in early adolescent offspring, and in turn, whether EAH was cross-sectionally associated with body composition.

Methods

We included data from 1097 adolescents participating in Project Viva, a pre-birth longitudinal cohort. We obtained the results of two-stage prenatal glycemic screening (50 g glucose challenge test, followed if abnormal by 100 g oral glucose tolerance test) at 26–28 weeks of gestation, and categorized mothers as having normal glucose tolerance, isolated hyperglycemia (IH, n = 92, 8.4%), impaired glucose tolerance (IGT, n = 36, 3.3%), or gestational diabetes mellitus (GDM, n = 52, 4.7%). At a median age of 13 years, offspring reported on two modified items of the Eating in the Absence of Hunger in Children and Adolescents questionnaire, we measured height and weight, and performed dual X-ray absorptiometry scans to assess fat and fat-free mass. We used multivariable linear regression analyses adjusted for sociodemographic and prenatal covariates, including maternal pre-pregnancy BMI.

Results

On a ten-point scale, the mean (SD) EAH score was 4.4 points (SD = 1.5) in boys and 4.4 (SD = 1.4) in girls. In girls, prenatal exposure to both IH and IGT was associated with more EAH compared with normal glucose tolerance (e.g., for IH: 0.56 points, 95% CI: 0.17, 0.96), whereas in boys, prenatal exposure to IGT was associated with less EAH (–0.81 points, 95% CI: −1.41, −0.21). We did not observe an association between exposure to GDM and EAH, nor did we observe associations between EAH and body composition in early adolescence.

Conclusions

These findings suggest sex-specific associations of exposure to impaired gestational glucose tolerance with offspring EAH in early adolescence.

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Acknowledgements

Project Viva is supported by the National Institutes of Health (R01 HD034568, UG3OD023286). We appreciate the dedication of Project Viva participants and staff. This study was supported by the Dutch KNAW Ter Meulen Foundation. PWJ is supported by the Dutch Diabetes Foundation (grant number: 2013.81.1664).

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Affiliations

  1. Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC- University Medical Center, Rotterdam, The Netherlands

    • Ivonne P. M. Derks
    •  & Pauline W. Jansen
  2. Division of Chronic Disease Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA

    • Ivonne P. M. Derks
    • , Marie-France Hivert
    • , Sheryl L. Rifas-Shiman
    • , Véronique Gingras
    • , Jessica G. Young
    •  & Emily Oken
  3. Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA

    • Marie-France Hivert
  4. Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands

    • Pauline W. Jansen
  5. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    • Emily Oken

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Ivonne P. M. Derks.

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DOI

https://doi.org/10.1038/s41366-018-0296-6