Article | Published:

Techniques and Methods

Adult energy requirements predicted from doubly labeled water

International Journal of Obesityvolume 42pages15151523 (2018) | Download Citation

Subjects

Abstract

Background

Estimating energy requirements forms an integral part of developing diet and activity interventions. Current estimates often rely on a product of physical activity level (PAL) and a resting metabolic rate (RMR) prediction. PAL estimates, however, typically depend on subjective self-reported activity or a clinician’s best guess. Energy-requirement models that do not depend on an input of PAL may provide an attractive alternative.

Methods

Total daily energy expenditure (TEE) measured by doubly labeled water (DLW) and a metabolic chamber from 119 subjects obtained from a database of pre-intervention measurements measured at Pennington Biomedical Research Center were used to develop a metabolic ward and free-living models that predict energy requirements. Graded models, including different combinations of input variables consisting of age, height, weight, waist circumference, body composition, and the resting metabolic rate were developed. The newly developed models were validated and compared to three independent databases.

Results

Sixty-four different linear and nonlinear regression models were developed. The adjusted R2 for models predicting free-living energy requirements ranged from 0.65 with covariates of age, height, and weight to 0.74 in models that included body composition and RMR. Independent validation R2 between actual and predicted TEE varied greatly across studies and between genders with higher coefficients of determination, lower bias, slopes closer to 1, and intercepts closer to zero, associated with inclusion of body composition and RMR covariates. The models were programmed into a user-friendly web-based app available at: http://www.pbrc.edu/research-and-faculty/calculators/energy-requirements/ (Video Demo for Reviewers at: https://www.youtube.com/watch?v=5UKjJeQdODQ)

Conclusions

Energy-requirement equations that do not require knowledge of activity levels and include all available input variables can provide more accurate baseline estimates. The models are clinically accessible through the web-based application.

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Author information

Affiliations

  1. Department of Mathematical Sciences, United States Military Academy, West Point, NY, USA

    • Andrew Plucker
    •  & Diana M. Thomas
  2. Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA

    • Nick Broskey
    • , Corby K. Martin
    • , Steven B. Heymsfield
    •  & Leanne A. Redman
  3. University of Wisconsin, Madison, WI, USA

    • Dale Schoeller
  4. Department of Pediatrics, Children’s Mercy, Kansas City, MO, USA

    • Robin Shook
  5. Mayo Clinic, Rochester, MN, USA

    • James A. Levine
  6. Ipsen Foundation, Paris, France

    • James A. Levine

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Diana M. Thomas.

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DOI

https://doi.org/10.1038/s41366-018-0168-0