Overweight and obesity are highly prevalent throughout the world and can adversely affect the nutritional status of individuals. Studies have shown that many people with obesity have inadequate intake of iron, calcium, magnesium, zinc, copper, folate and vitamins A and B12, likely as a result of poor diet quality. Nutritional inadequacies or deficiencies may also occur due to altered pharmacokinetics in the individual with obesity and due to interactions in those with overweight or obesity with various pharmaceuticals. However, it has been demonstrated that the adult population in the United States as a whole is deficient in certain micronutrients as a result of the availability and overconsumption of high-calorie, low-nutrient processed foods. Poor nutrition may contribute to the development of certain chronic conditions, such as type 2 diabetes, which is already more prevalent in those with obesity. Clinicians need to be aware of these gaps, particularly in those individuals with obesity who are undergoing bariatric surgery or taking pharmaceutical products long term to facilitate weight loss. Patients with overweight or obesity likely struggle to achieve a balanced diet and may benefit from consultation with a dietitian. Along with providing recommendations for healthy eating and exercise, supplementation with specific micronutrients or multivitamins should be considered for individuals at the highest risk for or with established deficiencies. Further research is needed to understand the factors underlying nutritional inadequacies in individuals with overweight or obesity, as well as the outcomes of treatment strategies employed to address them.
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Medical writing support was provided by Virginia A. Schad, PharmD, James C. Street, PhD, and Diane Sloan, PharmD, of Peloton Advantage, LLC, and was funded by Pfizer.
Both A.A and S.B. conceived this article, participated in its drafting and revision and approved it for submission.
Conflict of interest
Arne Astrup received an honorarium from Pfizer to review the literature on nutrient deficiencies in obesity and for the development of this manuscript. He has received research grant support from Arla Foods, Danish Dairy Research Foundation, Global Dairy Platform, Danish Agriculture and Food Council and GEIE European Milk Forum. He is an advisor to BioCare Copenhagen, Dutch Beer Institute, Feast Kitchen A/S, Groupe Ethique et Santé, IKEA, McCain Foods Limited, Zaluvida and Weight Watchers. He is a consultant for Basic Research, Beachbody, Gelesis, Danish Agriculture & Food Council, Nestlé Research Center, Novo Nordisk, Pfizer, Saniona, Sanofi Aventis, S-Biotek, Scandinavian Airlines System and Tetra Pak. He receives honoraria as Associate Editor of The American Journal of Clinical Nutrition and for membership of the Editorial Board of Annals of Nutrition and of Metabolism and Annual Review of Nutrition. Susanne Bügel, who did not receive an honorarium from Pfizer in connection with the development of this manuscript, has received research grants from The Software AG Foundation and ERASMUS+. She is a board member of Food, Quality and Health and the Federation of European Nutrition Societies and as such receives travel support for meetings supported by these organizations.
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Astrup, A., Bügel, S. Overfed but undernourished: recognizing nutritional inadequacies/deficiencies in patients with overweight or obesity. Int J Obes 43, 219–232 (2019). https://doi.org/10.1038/s41366-018-0143-9
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