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Epidemiology and Population Health

Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study

Abstract

Background

Although weight gain in mid- to late adult life is associated with an increased risk of colon cancer, it is unclear if increases or losses in weight from childhood to early adulthood are differentially associated with risks of adult colon cancer.

Methods

Weight and height were measured at 7 or 13 years and in early adulthood (17–26 years) in 64,675 boys in the Copenhagen School Health Records Register and the Danish Conscription Database. Cases of colon cancer (n = 751) were identified in the Danish Cancer Registry. Boys and young men were categorized as normal weight or overweight. Associations between changes in weight and colon cancer were examined using Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Compared with men with a normal weight at 7 years and in early adulthood, men with overweight at both ages had an increased risk of adult colon cancer (HR: 2.73, 95% CI 1.80–4.15). In contrast, men with overweight at 7 years, but not in early adulthood did not have an increased risk of colon cancer (HR: 0.73, 95% CI 0.35–1.54), nor did men with a normal weight at 7 years and overweight in early adulthood (HR: 1.28, 95% CI 0.96–1.70). Similar results were observed for weight status at age 13 years combined with early adulthood.

Conclusions

Childhood overweight that persists into early adulthood is associated with an increased risk of colon cancer, whereas overweight that disappears before early adulthood or developed after childhood is not.

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References

  1. 1.

    Lauby-Secretan B,Scoccianti C,Loomis D,Grosse Y,Bianchini F,Straif K, Body fatness and cancer — viewpoint of the IARC Working Group. N Engl J Med. 2016;375:794–8.

    Article  Google Scholar 

  2. 2.

    Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371:569–78.

    Article  Google Scholar 

  3. 3.

    Jensen BW, Gamborg M, Gogenur I, Renehan AG, Sørensen TIA, Baker JL. Childhood body mass index and height in relation to site-specific risks of colorectal cancers in adult life. Eur J Epidemiol. 2017;32:1097–106.

    CAS  Article  Google Scholar 

  4. 4.

    Levi Z, Kark JD, Katz LH, Twig G, Derazne E, Tzur D, et al. Adolescent body mass index and risk of colon and rectal cancer in a cohort of 1.79 million Israeli men and women: a population-based study. Cancer. 2017;123:4022–30.

    Article  Google Scholar 

  5. 5.

    Abarca-Gómez L, Abdeen ZA, Hamid ZA, Abu-Rmeileh NM, Acosta-Cazares B, Acuin C, et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet. 2018;390:2627–2642

  6. 6.

    Keum N, Greenwood DC, Lee DH, Kim R, Aune D, Ju W et al. Adult weight gain and adiposity-related cancers: a dose-response meta-analysis of prospective observational studies. J Natl Cancer Inst. 2015;107:djv088.

  7. 7.

    Schlesinger S, Lieb W, Koch M, Fedirko V, Dahm CC, Pischon T, et al. Body weight gain and risk of colorectal cancer: a systematic review and meta-analysis of observational studies. Obes Rev. 2015;16:607–19.

    CAS  Article  Google Scholar 

  8. 8.

    Karahalios A, English DR, Simpson JA. Weight change and risk of colorectal cancer: a systematic review and meta-analysis. Am J Epidemiol. 2015;181:832–45.

    Article  Google Scholar 

  9. 9.

    Zhang X, Wu K, Giovannucci EL, Ma J, Colditz GA, Fuchs CS, et al. Early life body fatness and risk of colorectal cancer in u.s. Women and men-results from two large cohort studies. Cancer Epidemiol Biomark Prev. 2015;24:690–7.

    CAS  Article  Google Scholar 

  10. 10.

    Song M, Willett WC, Hu FB, Spiegelman D, Must A, Wu K, et al. Trajectory of body shape across the lifespan and cancer risk. Int J Cancer. 2016;138:2383–95.

    CAS  Article  Google Scholar 

  11. 11.

    Meza R, Jeon J, Renehan AG, Luebeck EG. Colorectal cancer incidence trends in the United States and United kingdom: evidence of right- to left-sided biological gradients with implications for screening. Cancer Res. 2010;70:5419–29.

    CAS  Article  Google Scholar 

  12. 12.

    Baker JL, Olsen LW, Andersen I, Pearson S, Hansen B, Sørensen TIA. Cohort profile: the Copenhagen School Health Records Register. Int J Epidemiol. 2009;38:656–62.

    Article  Google Scholar 

  13. 13.

    Pedersen CB. The Danish Civil Registration System. Scand J Public Health. 2011;39(7 Suppl):22–5.

    Article  Google Scholar 

  14. 14.

    Christensen GT, Molbo D, Ängquist LH, Mortensen EL, Christensen K, Sørensen TIA, et al. Cohort profile: the Danish Conscription Database (DCD): a cohort of 728,160 men born from 1939 through 1959. Int J Epidemiol. 2015;44:432–40.

    Article  Google Scholar 

  15. 15.

    Gjerstorff ML. The Danish Cancer Registry. Scand J Public Health. 2011;39(7 Suppl):42–5.

    Article  Google Scholar 

  16. 16.

    Cole TJ, Lobstein T. Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr Obes. 2012;7:284–94.

    CAS  Article  Google Scholar 

  17. 17.

    WHO Technical Report Series, No. 854. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. In. Geneva, 1995;854:1-452.

  18. 18.

    Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94:496–509.

    Article  Google Scholar 

  19. 19.

    Le Marchand L, Wilkens LR, Mi MP. Obesity in youth and middle age and risk of colorectal cancer in men. Cancer Causes Control. 1992;3:349–54.

    Article  Google Scholar 

  20. 20.

    Renehan AG, Flood A, Adams KF, Olden M, Hollenbeck AR, Cross AJ, et al. Body mass index at different adult ages, weight change, and colorectal cancer risk in the National Institutes of Health-AARP Cohort. Am J Epidemiol. 2012;176:1130–40.

    Article  Google Scholar 

  21. 21.

    Bassett JK, Severi G, English DR, Baglietto L, Krishnan K, Hopper JL, et al. Body size, weight change, and risk of colon cancer. Cancer Epidemiol Biomark Prev. 2010;19:2978–86.

    Article  Google Scholar 

  22. 22.

    Renehan AG, Zwahlen M, Egger M. Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat Rev Cancer. 2015;15:484–98.

    CAS  Article  Google Scholar 

  23. 23.

    Larsson SC, Wolk A. Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr. 2007;86:556–65.

    CAS  Article  Google Scholar 

  24. 24.

    Harriss DJ, Atkinson G, George K, Cable NT, Reilly T, Haboubi N, et al. Lifestyle factors and colorectal cancer risk (1): systematic review and meta-analysis of associations with body mass index. Colorectal Dis. 2009;11:547–63.

    CAS  Article  Google Scholar 

  25. 25.

    Moghaddam AA, Woodward M, Huxley R. Obesity and risk of colorectal cancer: a meta-analysis of 31 studies with 70,000 events. Cancer Epidemiol Biomark Prev. 2007;16:2533–47.

    Article  Google Scholar 

  26. 26.

    Bua J, Olsen LW, Sørensen TIA. Secular trends in childhood obesity in Denmark during 50 years in relation to economic growth. Obesity (Silver Spring). 2007;15:977–85.

    Article  Google Scholar 

Download references

Acknowledgements

The CSHRR was established by the former Institute of Preventive Medicine (now the Center for Clinical Research and Prevention). It was built in collaboration with the Copenhagen City Archives in Denmark. The authors thank Kaare Christensen, Drude Molbo and Erik L. Mortensen, who together with MOand TIAS established the Danish Conscription Database.

Funding

This work was supported by the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013) [ERC Grant Agreement no. 281419 to JLB]; the Danish Council for Independent Research (DFF) [FSS Grant Agreement no. 1331-00218 to JLB] and Dagmar Marshals Fond [to BWJ].

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Correspondence to Jennifer L. Baker.

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The authors declare that they have no conflict of interest.

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Jensen, B.W., Bjerregaard, L.G., Ängquist, L. et al. Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study. Int J Obes 42, 1797–1803 (2018). https://doi.org/10.1038/s41366-018-0109-y

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