Article | Published:

Epidemiology and Population Health

Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study

International Journal of Obesity (2018) | Download Citation

Abstract

Background

Although weight gain in mid- to late adult life is associated with an increased risk of colon cancer, it is unclear if increases or losses in weight from childhood to early adulthood are differentially associated with risks of adult colon cancer.

Methods

Weight and height were measured at 7 or 13 years and in early adulthood (17–26 years) in 64,675 boys in the Copenhagen School Health Records Register and the Danish Conscription Database. Cases of colon cancer (n = 751) were identified in the Danish Cancer Registry. Boys and young men were categorized as normal weight or overweight. Associations between changes in weight and colon cancer were examined using Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Compared with men with a normal weight at 7 years and in early adulthood, men with overweight at both ages had an increased risk of adult colon cancer (HR: 2.73, 95% CI 1.80–4.15). In contrast, men with overweight at 7 years, but not in early adulthood did not have an increased risk of colon cancer (HR: 0.73, 95% CI 0.35–1.54), nor did men with a normal weight at 7 years and overweight in early adulthood (HR: 1.28, 95% CI 0.96–1.70). Similar results were observed for weight status at age 13 years combined with early adulthood.

Conclusions

Childhood overweight that persists into early adulthood is associated with an increased risk of colon cancer, whereas overweight that disappears before early adulthood or developed after childhood is not.

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Acknowledgements

The CSHRR was established by the former Institute of Preventive Medicine (now the Center for Clinical Research and Prevention). It was built in collaboration with the Copenhagen City Archives in Denmark. The authors thank Kaare Christensen, Drude Molbo and Erik L. Mortensen, who together with MOand TIAS established the Danish Conscription Database.

Funding

This work was supported by the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013) [ERC Grant Agreement no. 281419 to JLB]; the Danish Council for Independent Research (DFF) [FSS Grant Agreement no. 1331-00218 to JLB] and Dagmar Marshals Fond [to BWJ].

Author information

Affiliations

  1. Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark

    • Britt W. Jensen
    • , Lise G. Bjerregaard
    • , Lars Ängquist
    •  & Jennifer L. Baker
  2. Department of Surgery, Zealand University Hospital, Copenhagen University, Køge, Denmark

    • Ismail Gögenur
  3. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom

    • Andrew G. Renehan
  4. Research Center for Prevention and Health, Rigshospitalet- Glostrup, Glostrup, Denmark

    • Merete Osler
  5. Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    • Thorkild I. A. Sørensen
    •  & Jennifer L. Baker
  6. Department of Public Health, Section of Epidemiology, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark

    • Thorkild I. A. Sørensen

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Jennifer L. Baker.

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DOI

https://doi.org/10.1038/s41366-018-0109-y

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