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A genome-wide association study on photic sneeze syndrome in a Japanese population

Journal of Human Geneticsvolume 63pages765768 (2018) | Download Citation

Abstract

Photic sneeze syndrome (PSS) is characterized by a tendency to sneeze when the eye is exposed to bright light. Recent genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) associated with PSS in Caucasian populations. We performed a GWAS on PSS in Japanese individuals who responded to a web-based survey and provided saliva samples. After quality control, genotype data of 210,086 SNPs in 11,409 individuals were analyzed. The overall prevalence of PSS was 3.2%. Consistent with previous reports, SNPs at 3p12.1 were associated with PSS at genome-wide significance (p < 5.0 × 10−8). Furthermore, two novel loci at 9q34.2 and 4q35.2 reached suggestive significance (p < 5.0 × 10−6). Our data also provided evidence supporting the two additional SNPs on 2q22.3 and 9q33.2 reportedly associated with PSS. Our study reproduced previous findings in Caucasian populations and further suggested novel PSS loci in the Japanese population.

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Affiliations

  1. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan

    • Daimei Sasayama
    •  & Hiroshi Kunugi
  2. Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Nagano, 390-8621, Japan

    • Daimei Sasayama
  3. Genequest Inc., 5-22-37, Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-0022, Japan

    • Shinya Asano
    • , Shun Nogawa
    • , Shoko Takahashi
    •  & Kenji Saito

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Conflict of interest

This work was supported by internal funding from Genequest Inc. and an NCNP Intramural Research Grant for Neurological and Psychiatric Disorders (HK, grant number 27-1). These sources provided financial support only. KS and ST are board members, and SA and SN are employees of Genequest Inc. The remaining authors declare that they have no conflict of interest.

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Correspondence to Hiroshi Kunugi.

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DOI

https://doi.org/10.1038/s10038-018-0441-z