Abstract
Background and Aims: Early extubation to nasal continuous positive airway pressure (nCPAP) may decrease bronchopulmonary dysplasia (BPD) or death in extremely low birth weight (ELBW; birth weight < 1000g) infants. We present our experience on ELBW infants extubated early (within first 24 hours).
Methods: Electronic records were retrieved for all inborn ELBW infants between April 2007 and October 2010. We reviewed birth weight, gestation, gender, failed extubations (re-intubated within 7 days) and outcomes (BPD, death) of ELBW infants extubated within the first 24 hours following birth. Continuous variables were compared using Student's t test and discrete variables were compared by Chi-squared test at 95% significance.
Results: Ninety-five infants were identified, 50 females and 45 males. Fifty-six (59%) were extubated within 24 hours after birth, 37 (39%) after day 1 but within 7 days, and 2 (2%) did not require intubation. Twenty (36%) infants extubated in the first 24 hours required re-intubation within 7 days. Infants extubated in the first 24 hours were significantly more mature (26.9 ± 1.4 weeks vs. 25.3 ± 1.4 weeks, p< 0.0001), had greater birth weights (826 ± 118g vs. 738 ± 145g, p< 0.002) and more likely to be alive at discharge compared to babies extuabted after 24 hours (80% vs. 54%, p< 0.05). Composite outcome for death or BPD was significantly lower (46% vs. 73%, p< 0.05) in this group.
Conclusions: The majority of ELBW infants were extubated within 24 hours following birth. These infants were at significantly decreased risk of death or BPD.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brugha, R., Gritz, A., Chow, P. et al. Outcome of Extremely Low Birth Weight Infants Extubated. Pediatr Res 70 (Suppl 5), 624 (2011). https://doi.org/10.1038/pr.2011.849
Issue Date:
DOI: https://doi.org/10.1038/pr.2011.849