Abstract
Aims: The aim of this present study is to compare the changes in cerebral blood volume (CBV) among term and preterm infants during the early postnatal period by using near infrared time resolved spectroscopy (NIR-TRS).
Method: Optodes were placed on the front of the head and the right upper arm of neonates. The cerebral total hemoglobin (ctHb) level, peripheral total hemoglobin (ptHb) level, and SrO2 were measured using NIR-TRS at 3-6, 12, 24, 48, and 72 h after birth. The CBV, fractional cerebral tissue oxygen extraction (FTOE) and ctHb/ptHb were calculated. The MABP, HR, SpO2, PCO2, blood Hb level and Ht were measured. All the data were statistically analysed.
Result: Twenty-three term infants (term group) and 36 preterm infants (preterm group) were observed. The preterm group was divided into 2 subgroups: the LBW subgroup (21 infants; 1,500 g < BW < 2,500 g) and the VLBW subgroup (15 infants; BW < 1,500 g). The CBVs for the term group were significantly higher than those for the preterm group throughout the study period. The CBVs for the VLBW subgroup were significantly higher than those for the LBW subgroup at 24, 48 and 72 h after birth. The ctHb/ptHb for the term group was significantly higher than that for the preterm group throughout the study period. CBV and Ht were negatively correlated in 3 groups.
Conclusion: The changes in the CBV pattern differed between term and preterm infants. The CBVs for VBLW infants were higher than those for LBW infants.
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Fujioka, T., Takami, T., Ishii, H. et al. Comparison of the Time Course Changes in Cerebral Blood Volume among Different Birth Weight Groups of Neonates During the First 3 Days of Life. Pediatr Res 70 (Suppl 5), 241 (2011). https://doi.org/10.1038/pr.2011.466
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DOI: https://doi.org/10.1038/pr.2011.466