Abstract
Objectives: Autism is classified as global neuro-development disorder especially in behavioral disability. The aim of this study is to evaluate the pattern of electroencephalogram (EEG) in chinese autistic children with or without clinical epilepsy.
Methods: A retrospective chart review of autistic children conducted from outpatient clinics in one medical center from March, 2007 to December, 2010 with cases followed-up at least twice at the same outpatient clinic. The demography of the patients, the standard EEG records, and clinical epilepsy were reviewed.
Results: A total of 139 EEGs of autistic spectrum children were enrolled, age ranging from 2y10m to 18 years (means: 7.8years). Male was predominant with the ratio 4:1. Among 139 EEG studies, abnormal EEG was noted in 57 cases. (Male: female 42:15) Twenty-six (46%) of these 57 cases had multifocal epileptiform discharges, twelve cases (21%) had localized epileptiform discharges, 4 (7%) had both multifocal epileptiform discharges with secondary generalized. Localized frontal region epileptiform discharge was found predominantly (56%). A higher percentage of epilepsy especially in female population rather than male was found in those with abnormal EEG findings (40%: 29%).
Conclusions: EEG abnormality only occurs in a certain number of autistic children. The frontal region predominance of EEG discharges associated with beta wave might implicate its major patho-physiological basis in autistic patients. Female autistic children have a clinical significance incidence of underlining seizure activities.
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Lim, A. The Analysis of the Electro-Encephalogram in Chinese Children with Autistic Spectrum Disorders. Pediatr Res 70 (Suppl 5), 184 (2011). https://doi.org/10.1038/pr.2011.409
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DOI: https://doi.org/10.1038/pr.2011.409