Objective: This study sought to summarize the clinical data of children who were admitted in Beijing Children's hospital with a diagnosis of hypertension, and try to analyze the discriminating factors between primary hypertension and secondary hypertension.
Methods: All children who were admitted to Beijing Children's Hospital during 2003 through 2007 were enrolled. Data on medical history, physical examination and laboratory studies were recorded. Hypertension was diagnosed according to the Chinese guideline for childhood hypertension and American national high blood pressure education program criteira. Hypertension was classified as primary and secondary based on the etiology of hypertension.
Results: A total of 304 children were included. Out of them, 146 (48.0%) children were classified as primary hypertension, 158 (52.0%) were secondary hypertension. Renal hypertension is the first etiology in secondary hypertension, followed by hypertension due to endocrine system diseases, cardiovascular system and central nervous system. Multiple logistic regression showed positive family history of hypertension (OR=8.897), age of older than 10 years (OR=10.176) and increased BMI (OR=19.256) were independent risk factors of primary hypertension, while ST-T changes on electrocardiogram (OR=0.0257), erecting serum renin angiotensin > 6ng/ml.h (OR=0.0593) were risk factors of secondary hypertension.
Conclusions: Secondary hypertension is more common in children admitted. Family history of hypertension, age of older than 10 years, increased BMI were risk factors of primary hypertension, while ST-T changes on electrocardiogram, erecting serum renin angiotensin > 6ng/ml.h were risk factors of secondary hypertension.