Abstract
Objectives: Concerns have been raised regarding the existence of endothelial damage and the possibility of a predisposition to premature atherosclerosis in young adulthood with a history of Kawasaki disease (KD). This study was designed to evaluate the Circulating endothelial progenitor cells (EPC) and the serum lipoprotein levels and high sensitivity C-reactive protein in children with coronary aneurysms.
Methods: Thirty-one children with coronary aneurysms due to KD and 21 healthy controla were enrolled. Circulating EPC were determined by flow cytometry, and defined as CD34/ KDR/CD133+ cells. Serum hs-CRP levels were determined by euzymelinked immunosorbent assay.
Results: The KD group included 9 children with medium aneurysms and 22 children with gaint aneurysms. The duration from the onset of the disease was 1-12.5 years (median 2.53 years). One children had angina pectris, another had heart failure and abnormal Q waves. The hs-CRP levels in KD group was significantly higher than in normal controls (2.77±1.06 mg/L VS 1.60±1.53mg/L, P< 0.01). The number of circulating EPCs between the two groups had no statistical significance (P>0.05). The serum levels of TG, TC, HDL-C, LDL-C apo-A1 and apo-B between the two groups had no statistical significance (P>0.05).
Conclusions: The serum level of hs-CRP were significantly increased in KD group, while circulating EPC and serum lipoprotein levels have no significant differences between the two groups. This suggest that children with persistant coronary aneurysms due to Kawasaki disease may have the disposition to premature atherosclerosis in young adulthood.
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Du, ZD., Duan, C. & Wan, SG. 613 The Study of Circulating Endothelial Progenitor Cells and Related Inflammatory Factors in Children with Coronary Aneurysms Late After Kawasaki Disease. Pediatr Res 68 (Suppl 1), 314 (2010). https://doi.org/10.1203/00006450-201011001-00613
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DOI: https://doi.org/10.1203/00006450-201011001-00613