Abstract
Objective:
-
1. Magnesium levels in neonates and infants with Transposition of Great Arteries undergoing the Arterial Switch Operation.
-
2. Role of Magnesium supplementation in prevention of post operative arrythmias in these infants.
Material and Methods: After ethical clearance and written informed consent from the parents, Neonates and infants undergoing the Arterial Switch operation were randomly assigned to one of two groups. Group 1 (n=25) was given intravenous Magnesium Sulphate 30 mg /kg in 5 ml Normal saline, immediately after cessation of cardiopulmonary bypass, while Group II (n = 25) was given 5 ml of Normal saline as a placebo. Blood samples were taken after induction of anaesthesia, after stabilisation on cardiopulmonary bypass, during rewarming, and 4 hours after admission to the intensive care unit. The samples were analysed for arterial blood gases, and electrolytes including Na+, K+, ionised Ca++, ionised Mg++. Continuous ECG rhythm analysisand documentation of arrythmias was performed for 24 hours in the intensive care.
Results: Both the groups were comparable with regard to demographic data. Mean preoperative ionised Mg++ levels were below normal in both the groups, at 0.30 (±0.11)mmol/L in group I and 0.30(±0.8)mmol/L in group II. Serum ionised Mg++increased during rewarming period of cardiopulmonary bypass, in both groups.
In the intensive care, Mg++ levels in group I, 0.74 (±0.25) mmol/L wasgreater than groupII 0.40(±0.06) mmol/L. Only 1 child out of 25 (4%) inGroupI, had junctional tachycardia, while 5out of 25children in groupII (20%) had junctional (4/25-16%) and1child hadsupraventricular tachycardia (4%).
Conclusions: Serum Mg++levels are low preoperatively in neonates/infants undergoing thearterial switchoperation, Mg++supplementation helps in reducing postoperative arrythmias in these children.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chauhan, S., Verma, Y. & Bisoi, A. 610 Role of Magnesium in Preventing Postoperative Arrythmias in Neonates and Infants Undergoing the Arterial Switch Operation. Pediatr Res 68 (Suppl 1), 312–313 (2010). https://doi.org/10.1203/00006450-201011001-00610
Issue Date:
DOI: https://doi.org/10.1203/00006450-201011001-00610