Abstract
We investigated the association between indicators of fetal growth and neonatal stress and CNS tumours diagnosed in the Denmark, Sweden, Norway and Finland in 1985-2006, using data from national cancer registries and medical birth registries. We included 3,443 children with primary CNS tumours and 16169 individually matched controls drawn randomly from the national population registries.
We observed a U-shaped relation between risk for CNS tumors and birthweight, at >4.5 kg (OR 1.27; 95% CI, 1.03-1.55) and < 2.0 kg (OR, 1.50; 95% CI, 1.13-1.99), the latter being attenuated after adjustment for gestational age. Moreover, small-forgestational age (OR, 1.28; 95% CI, 0.98-1.66) and large-forgestationalage (OR, 1.26; 95% CI, 1.02- 1.55) were both associated with CNS tumors. The OR for preterm births was increased per 1-week decrease in gestational age (OR, 1.58; 95% CI, 1.04-2.44). Increased Ors were also observed for head circumference >38 cm (1.80; 95% CI, 1.18- 2.74), 5-minute Apgar score < 7 (1.44;95% CI, 0.98-2.12), and breech presentation (1.33; 95% CI, 1.04-1.69). The observed associations varied little by histologic subgroup.
This study provides evidence that several intrauterine and neonatal factors are associated with higher risk of CNS tumours, indicating an early onset or, alternatively, potentially harmful exposures in the neonatal period that might be preventable.
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Schmidt, L., Schüz, J., Lähteenmäki, P. et al. 420 Fetal Growth, Preterm Birth, Neonatal Stress and Risk for Cns Tumors in Children: A Nordic Populationand Register-Based Case- Control Study. Pediatr Res 68 (Suppl 1), 216 (2010). https://doi.org/10.1203/00006450-201011001-00420
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DOI: https://doi.org/10.1203/00006450-201011001-00420