Abstract
Background: Traditional risk factors for cardiovascular disease such as an abnormal lipid profile, hypertension, obesity, and insulin resistance contribute to the accelerated atherosclerosis seen in young persons with T1D. Gender, ethnic origin, pubertal status and metabolic control might influence these parameters during childhood.
Aims: To compare the prevalence of dyslipidemia, hypertension as well as global and abdominal obesity between Flemish and Maghreb children receiving similar standard medical care and to analyze the relationship of these parameters with serum hS CRP and fibrinogen, as parameters of a general state of inflammation, which can be considered as a precursor of atherosclerosis.
Patients and Methods: At their annual check up, fasting lipid levels, hS CRP, fibrinogen, blood pressure, body weight and length as well as waist circumference were determined in children and adolescents with T1DM at least 1 year after diagnosis and without familial hypercholesterolemia or treatment with statins. Anthropometric data were expressed as z-scores for age using recent Flemish population references (2004). ISPAD defined target levels (2009) for lipid levels were used.
Conclusion: Type 1 diabetes children from Maghreb origin have a higher degree of obesity, but similar lipid levels than innate children.
Elevated LDL is the most frequently encountered cardiovascular risk factor using the ISPAD cut-offs Inflammation as well as elevated LDL can already be observed in pre-pubertal children with type 1 diabetes, unrelated to their metabolic control.
HbA1c correlated significantly with diastolic blood pressure and serum triglycerides but also with parameters for subclinical atherosclerosis as fibrinogen and hs CRP.
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Dewals, W., Gies, I., Vanbesien, J. et al. 405 Cardiovascular Risk Factors in Children with Type 1 Diabetes: A Crosssectional Study of a Mixed Flemishmaghreb Population in Brussels. Pediatr Res 68 (Suppl 1), 208 (2010). https://doi.org/10.1203/00006450-201011001-00405
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DOI: https://doi.org/10.1203/00006450-201011001-00405