Abstract
Background and aims: The aim is to evaluate and compare the efficacy and side effects of oral and intravenous(IV) ibuprofen for treatment of PDA in preterm infants.
Methods: A prospective, randomized controlled trial was conducted in premature neonates with gestational ages(GA) < 32weeks, birth weight(BW) < 1500g, at Ankara University NICU between January 2008 to January 2010. Infants who had defined symptoms for PDA together with echocardiographically demonstrated ductus and presymptomatic infants with a ductus diameter/kg>1,5 or with a left atrium/aorta ratio>1,5 detected on routine echocardiogram in the 2nd day of life were included in the study. Three doses of either oral or IV ibuprofen were randomly given at a dosage of 10,5,5mg/kg every 24 hours. Daily physical examination, serial laboratory evaluation and echocardiogram were used to evaluate symptomatic PDA, treatment outcomes, complications and side effects.
Results: Thirty-three infants were recruited during two years period and randomly assigned into the groups. Twenty of them received IV ibuprofen. The GA, BW, presence of antenatal corticosteroid, APGAR scores, use of surfactant, ductus diameters, La/Ao ratio of the two groups were similar. Closure, reopening and need for surgical ligation didn't differ between groups. There were no significant difference in the prevalence of NEC, renal dysfunction and mortality between two groups.
Conclusions: In this study oral ibuprofen is shown to be as effective as IV form for the treatment of PDA, with similar side effects. Considering the cost and availability of IV form, it can be the drug of choice.
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Akin, M., Okulu, E., Atasay, B. et al. 225 Oral Vs Intravenous Ibuprofen for Treatment of Patent Ductus Arteriosus. Pediatr Res 68 (Suppl 1), 117–118 (2010). https://doi.org/10.1203/00006450-201011001-00225
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DOI: https://doi.org/10.1203/00006450-201011001-00225