Abstract
Background: Antibodies against cyclic citrullinated peptides (CCP) are useful for diagnosing Rheumatoid Arthritis and Juvenile Idiopathic Arthritis (JIA). Antibodies to mutated citrullinated vimentin (MCV) were recently described in Rheumatoid Arthritis in adults.
The aim of the study was to evaluate the diagnostic and prognostic value of anti-MCV in JIA comparing to anti-CCP.
Methods: 30 children (19 girls and 11 boys; aged 4 -18 years) with confirmed JIA diagnosis and 20 children as a control group were included into the study. Anti-CCP and anti-MCV antibodies in sera were measured using ELISA test.
Results: Sensitivity and specificity of the anti-CCP were 40% and 100% compared with 36,7% and 90% for the anti-MCV calculated using manufactures recommended cut-off values.
Anti-MCV were positive in 11/30 comparing with 12/30 for anti-CCP in children with JIA. Among 11 JIA children positive for anti-MCV, 5 were also positive for anti-CCP and among 18 JIA children negative for anti-CCP, 6 were positive for anti-MCV. Both antibodies were mainly observed in polyarthritis, however could be positive in other types of JIA.
Anti-MCV serum concentration correlated positively with anti-CCP (p=0,0018). Anti-CCP correlated positively with disease activity (p=0,00196), radiological destruction in joints (p=0,00196) at baseline and after median 11,5 months of follow up (p=0,00961), but these correlations were not observed concerning anti-MCV (respectively: p=0,0657; p=0,06199; p=0,064).
Conclusions: Anti-MCV as well as anti-CCP antibodies could be helpful in the diagnosis of JIA. However, the anti-CCP prognostic value in JIA appears to be superior to the anti-MCV test.
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Lipinska, J., Smolewska, E., Brozik, H. et al. 848 Anti-MCV and Anti-CCP Antibodies - Diagnostic and Prognostic Value in Children with Juvenile Idiopathic Arthritis. Pediatr Res 68 (Suppl 1), 425 (2010). https://doi.org/10.1203/00006450-201011001-00848
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DOI: https://doi.org/10.1203/00006450-201011001-00848