Abstract
Background: Hepatitis c virus (HCV) is a hepatotrop virus which causes chronic hepatitis and some important complications.One of important way for spreading of this virus is blood products transfusion.In Iran,the donor's blood in blood transfusion organization has been screened for HCV from 1996. We decided to determine the frequency of this disease in persons who received blood products before 1996 due to acute illness accidentally.
Methods: This study was performed a case-control in persons between 7–18 years of age in two equal groups which attend in Amirkola children hospital in Babol for any reason during 2003
In case group there were persons who received different kinds of blood products,but no person in control group received any blood products.The first,2cc of venous blood sample from each person in two groups was prepared and screened for HCV antibody by Eliza and then the positive one was examined by PCR.Exclusion criterias in our study were age less than 7 and greater than 18 years old, immunocompromised patients,who received multiple blood transfusion for their chronic diseases and also patients who received multiple blood transfusion for their chronic disease and also patients who received blood products after 1996.Statistical analysis with SPSS software and fisher test was performed. P value <0.05 was significant
Results: There were 100 persons in case group and 100 persons in control group.In case group 2 persons (2%) were HCV antibody positive which one of them (1%) was confirmed by PCR,but in control group, there was no infected person (P=0.5).
Conclusion: Infectivity to hepatitis C virus in persons who received blood products for acute illness before 1996 was more than control group but the differences two groups was not significant statistically.It seems to be necessary to do a larger study and a special attention of HCV in these persons.
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Esmaeilidooki, M., Mostafazadeh, A., Sharbatdaran, M. et al. 110 Hepatitis C in Blood Products Receivers Due to Acute Illness Before Screening Program. Pediatr Res 58, 373 (2005). https://doi.org/10.1203/00006450-200508000-00139
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DOI: https://doi.org/10.1203/00006450-200508000-00139