Abstract
Kawasaki Disease (KD) is an acute vasculitis of young childfood. However, little is known about the pathogenesis and immune response of KD. In this study, autoantigens of KD recognized by the host humoral immune response were investigated by serological analysis of antigens by recombinant expression cloning(SEREX). Immmunoscreening of a cDNA expression library from human umbilical vascular endotherial cells, which have been activated by IL-1 and TNF-α, with serum from a KD patient identified more than 20 autoantigens, including several antigen processing related proteins. To analyze whether immunerecognition of these autoantigens was KD related, allogeneic sera samples obtained from normal blood donors, patients with KD and patients with other diseases were tested for reactivity against the autoantigens defined in the study.
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Kaneko, M., Ono, T., Matsubara, T. et al. Serological Analysis of Autoantigens of Kawasaki Disease by cDNA Expression Cloning. Pediatr Res 53, 169 (2003). https://doi.org/10.1203/00006450-200301000-00093
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DOI: https://doi.org/10.1203/00006450-200301000-00093