Abstract
Obesity, dyslipidemia, hypertension, insulin resistance, and type 2 diabetes or impaired glucose tolerance (IGT) especially in constellation, are known as metabolic syndrome. They are potent risk factors for coronary disease in adults. Objective: To estimate the prevalence of clustering of the metabolic syndrome in obese children and adolescents using the definition proposed by the World Health Organization (WHO, 1998). Materials and methods: 182 overweight children and adolescents (99 females, 83 males; age range 11.1± 2.1 yr) were selected among the children who consulted for obesity without clinical manifestations of other diseases. The metabolic syndrome was defined as presence of overweight or obesity and type 2 diabetes or IGT or insulin resistance normal glucose tolerance with at least one of the following risk factors: hypertension or dyslipidemia. Children with BMI > the 85 th percentile for age and sex reported on the BMI tables of Rolland Cachera were defined as overweight. All of the children were given an oral glucose tolerance test and venous blood samples were obtained to measure plasma glucose and insulin levels. Triglyceride concentrations were assessed at fasting samples. Blood pressure was measured at rest Systolic or diastolic hypertension was defined as a value grater than 95 th Plo of the tables of Task Force. Insulin resistance was assessed at baseline by using the homeostasis model assessment and considered abnormal a value greater than more than the mean and one SD of normal control. Type 2 diabetes and impaired glucose tolerance was defined according to the ADA guidelines. Results: A total of 46.1% of the patients had metabolic syndrome. The associations of obesity and the individuals conditions founded was Insulin resistance: 65,3%, hypertension: 58,2 % hypertrigliceridemia 21,8% and with impaired glucose tolerance 8,8%. The patients with metabolic syndrome were significativly more obese than the group without the syndrome BMI 32,9+- 5,9 vs 29.9+-5.3 (p<0.0005). Conclusions: The clustering of cardiovascular risk factors called metabolic syndrome based on the WHO definition is seen in 46,1 % the obese children and adolescents. It confers an increased risk of cardiovascular morbidity and its identifications may thus be important in the risk assessment and treatment of childhood obesity.
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Krochik, G., Ozuna, B. & Mazza, C. Risk Variable Clustering in the Metabolic Syndrome in Childhood Obesity. Pediatr Res 53, 870 (2003). https://doi.org/10.1203/00006450-200305000-00036
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DOI: https://doi.org/10.1203/00006450-200305000-00036