Abstract 207

Background:- Cystic fibrosis related diabetes (CFRD) is an increasingly recognized problem in cystic fibrosis (CF). There have only been a few cases of diabetic complications described in CFRD.

Aim:- To estimate the prevalence of microvascular and macrovascular complications in a large population with CF and CFRD.

Methods:- A 5 year retrospective study was performed of 648 children and adults with CF, and prevalence of microvascular and macrovascular diabetic complications noted. Early nephropathy was defined as persistent microalbuminuria (>20µg/min), and retinopathy as microaneurysms and/or haemorrhages and/or exudates. Macrovascular complications were defined as end-organ complications involving the heart, brain or limbs due to atheroma of the relevant vessels.

Results:- 61 (9%) of all patients, and 53 (16%) of the 326 adults developed CFRD. 51 of the 61 with CFRD had had endocrinological monitoring for a mean of 5.8 years, and 10 (20%) had nephropathy and/or retinopathy. 64% of those with CFRD for > 10 years had microvascular complications. None of the 51 had macrovascular complications.

Conclusion:- Microvascular, but not macrovascular, diabetic complications are common in patients with CFRD.